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Invitrogen
CLOCK Polyclonal Antibody
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CLOCK Antibody (PA3-16514) in WB
Western blot was performed using Anti-CLOCK Polyclonal Antibody (Product # PA3-16514) and a 95kDa band corresponding to CLOCK was observed across the cell lines and tissue extracts tested. Modified whole cell extracts (1% SDS) (30 µg lysate) of HeLa (Lane 1), A-431 (Lane 2), MCF-7 (Lane 3), MCF-7 treated with Beta Estradiol (1uM for 24hrs) (Lane 4), T-47D (Lane 5), PC-3 (Lane 6), NIH/3T3 (Lane 7), tissue extracts of Mouse Testis (Lane 8), Mouse Skeletal muscle (Lane 9), Rat Skeletal muscle (Lane 10) and Mouse Thymus (Lane 11) were electrop... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA3-16514
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Two peptides derived from mouse CLOCK conjugated to albumin.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
Conc. Not Determined
保存液
whole serum
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody has been tested against bacterially expressed fragment of CLOCK expressed in BL21 cells or the full length protein expressed in an in vitro translation system (reticulocyte lysate).
靶标信息
This gene encodes a protein that belongs to the basic helix-loop-helix (bHLH) family of transcription factors. Polymorphisms within the encoded protein have been associated with circadian rhythm sleep disorders. A similar protein in mice is a circadian regulator that acts as a transcription factor and forms a heterodimer with aryl hydrocarbon receptor nuclear translocator-like to activate transcription of mouse period 1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: circadian locomoter output cycles kaput; circadian locomoter output cycles kaput protein; circadian locomotor output cycles kaput; class E basic helix-loop-helix protein 8; clock homolog; KIAA0334; rCLOCK; transcription factor; unnamed protein product
基因别名: 5330400M04Rik; bHLHe8; KAT13D
UniProt ID: (Human) O15516, (Rat) Q9WVS9, (Mouse) O08785
Entrez Gene ID: (Human) 9575, (Rat) 60447, (Mouse) 12753
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
histone acetyltransferase activity
protein binding
chromatin DNA binding
sequence-specific DNA binding
protein dimerization activity
peptide-lysine-N-acetyltransferase activity
E-box binding
sequence-specific double-stranded DNA binding
DNA damage checkpoint
chromatin remodeling
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
protein acetylation
spermatogenesis
female pregnancy
circadian rhythm
response to light stimulus
entrainment of circadian clock
gene expression
regulation of gene expression
circadian regulation of gene expression
regulation of hair cycle
regulation of circadian rhythm
positive regulation of circadian rhythm
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of inflammatory response
regulation of insulin secretion
response to redox state
cellular response to ionizing radiation
regulation of type B pancreatic cell development
negative regulation of glucocorticoid receptor signaling pathway
signal transduction
photoperiodism
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