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Invitrogen
CLOCK Recombinant Rabbit Monoclonal Antibody (HL1099)
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CLOCK Antibody (MA5-42355) in WB
Western blot analysis of CLOCK in Untreated (-) and treated (+) 293T whole cell extracts (30 µg). Sample was separated with 7.5% SDS-PAGE, incubated with monoclonal CLOCK antibody (Product # MA5-42355) at a dilution of 1:1000, and followed by HRP-conjugated anti-rabbit IgG.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-42355
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL1099
抗原
Recombinant protein encompassing a sequence within the C-terminus region of human CLOCK. The exact sequence is proprietary.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
靶标信息
This gene encodes a protein that belongs to the basic helix-loop-helix (bHLH) family of transcription factors. Polymorphisms within the encoded protein have been associated with circadian rhythm sleep disorders. A similar protein in mice is a circadian regulator that acts as a transcription factor and forms a heterodimer with aryl hydrocarbon receptor nuclear translocator-like to activate transcription of mouse period 1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bHLHe8; circadian locomoter output cycles kaput; Circadian locomoter output cycles protein kaput; Class E basic helix-loop-helix protein 8; hCLOCK; mCLOCK; rCLOCK
基因别名: 5330400M04Rik; BHLHE8; CLOCK; KAT13D; KIAA0334
UniProt ID: (Mouse) O08785, (Rat) Q9WVS9
Entrez Gene ID: (Mouse) 12753, (Rat) 60447
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
core promoter sequence-specific DNA binding
core promoter binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription factor binding
DNA binding
transcription factor activity, sequence-specific DNA binding
histone acetyltransferase activity
signal transducer activity
protein binding
transcription factor binding
transferase activity
transferase activity, transferring acyl groups
chromatin DNA binding
sequence-specific DNA binding
protein dimerization activity
E-box binding
DNA damage checkpoint
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
cellular response to DNA damage stimulus
signal transduction
spermatogenesis
circadian rhythm
histone acetylation
circadian regulation of gene expression
regulation of hair cycle
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
positive regulation of inflammatory response
regulation of insulin secretion
positive regulation of NF-kappaB transcription factor activity
response to redox state
cellular response to ionizing radiation
regulation of type B pancreatic cell development
negative regulation of glucocorticoid receptor signaling pathway
entrainment of circadian clock
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