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Invitrogen
CLSTN1 Recombinant Rabbit Monoclonal Antibody (K01_2L90)
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产品信息
MA564028
应用
建议稀释比
已发表文章
产品规格
种属反应
Hamster,
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
K01_2L90
抗原
A synthetic peptide of human CLSTN1 (aa 969-981).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
50mM tris glycine, pH 7.4, with 150mM NaCl, 0.05% BSA, 40% glycerol
内含物
0.01% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: QQQLEWDDST LSY
靶标信息
CLSTN1 induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, CLSTN1 stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, CLSTN1 abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding.CLSTN1 may modulate calcium-mediated postsynaptic signals.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Alc-alpha; alcadein alpha; Alcadein-alpha; Alzheimer-related cadherin-like protein; cadherin-related family member 12; calsyntenin 1; Calsyntenin-1; FLJ32258; Non-classical cadherin XB31alpha
基因别名: 1810034E21Rik; ALC-ALPHA; alcalpha1; alcalpha2; CDHR12; CLSTN1; CS1; CST-1; CSTN1; I79_024775; KIAA0911; PIK3CD; XB31alpha
UniProt ID: (Human) O94985, (Mouse) Q9EPL2
Entrez Gene ID: (Human) 22883, (Mouse) 65945, (Chinese hamster) 100771175
