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Invitrogen
CNGB3 Polyclonal Antibody
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CNGB3 Antibody (PA5-103768) in ICC/IF
Immunocytochemistry analysis of CNGB3 in Hela cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with CNGB3 polyclonal antibody (Product # PA5-103768) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
产品信息
PA5-103768
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CNGB3(Accession Q9NQW8), corresponding to amino acid residues N90-R140.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total CNGB3.
靶标信息
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cng channel; CNG channel beta-3; cone photoreceptor cGMP-gated cation channel beta-subunit; Cone photoreceptor cGMP-gated channel subunit beta; cyclic nucleotide gated channel beta 6; Cyclic nucleotide-gated cation channel beta-3; Cyclic nucleotide-gated cation channel modulatory subunit; Cyclic nucleotide-gated channel beta-3; Cyclic nucleotide-gated channel subunit CNG6
基因别名: ACHM1; CCNC2; CNG6; CNGB3; Cngbeta2
UniProt ID: (Human) Q9NQW8, (Mouse) Q9JJZ9
Entrez Gene ID: (Human) 54714, (Mouse) 30952
transport
cation transport
signal transduction
visual perception
regulation of membrane potential
potassium ion transmembrane transport
ion transport
cyclic nucleotide metabolic process
regulation of ion transmembrane transport
response to stimulus
transmembrane transport
cation transmembrane transport
