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Invitrogen
CNIH2/CNIH3 (extracellular) Polyclonal Antibody
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CNIH2/CNIH3 (extracellular) Antibody (PA5-111788) in WB
Western Blot analysis of CNIH2/3 was performed in mouse (lanes 1 and 3) and rat (lanes 2 and 4) brain lysates. Lane 1,2: CNIH2/CNIH3 (extracellular) Antibody (Product # PA5-111788) at a dilution of 1:200. Lane 3,4: CNIH2/CNIH3 (extracellular) Antibody preincubated with the negative control antigen.
产品信息
PA5-111788
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide corresponding to amino acid residues 49-61 of rat CNIH2 (Extracellular loop)
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
保存条件
-20°C
运输条件
Wet ice
RRID
产品详细信息
Reconstitute antibody with 50 µL of double distilled water (DDW). The reconstituted solution can be stored at 4 degrees C for up to 1 week. For longer periods, small aliquots should be stored at -20 degrees C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Peptide sequence is: RARERLKNIE RIC
Homology: CNIH2 : Mouse, human identical.CNIH3 : Rat, mouse, human - 11/13 amino acid residues identical.
靶标信息
Cornichon homologs (CNIHs) are a family of AMPA-type glutamate receptor (AMPAR) auxiliary subunits that modulate AMPAR ion channel function and trafficking. Cornichon 2 and 3 (CNIH2/3) are responsible for controlling the export of AMPARs from the endoplasmic reticulum and associate with synaptic AMPARs to modulate channel kinetics. CNIHs are small proteins with three transmembrane domains that directly binds to AMPARs. Overexpression CNIHs and AMPA receptors causes their localization to the Golgi apparatus. CNIH and TARP both compete for the binding to AMPAR subunits GluA2, GluA3, and GluA4 subunits, suggesting both proteins bind to the same site. CNIH2/3 binding to AMPARs is dependent on AMPAR subunit composition and TARPs.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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