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Invitrogen
CNR2 Polyclonal Antibody
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产品信息
PA1-746A
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
已发表种属
C. elegans,
Hamster,
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
GST fusion protein containing the first 32 amino acid residues from Rat CB2.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol, 1mg/mL BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
PA1-746A detects cannabinoid receptor 2 (CB2) from human and rat tissues as well as transfected rat CB2.
PA1-746A has been successfully used in WB, immunocytochemistry, immunohistochemistry (paraffin) and FACS procedures. Immunocytochemical staining of CB2 into AtT20 cells transfected with the rat CB2 gene with PA1-746 yields a pattern consistent with plasma membrane staining.
靶标信息
Cannabinoids exert their well known physiological effects through two G protein coupled receptors, cannabinoid receptor 1 (CB1) and CB2. Both cannabinoid receptors have been shown to inhibit adenylyl cyclase as well as stimulate the mitogen-activated protein kinase, MAPK. CB1 receptors also modulate ion channels through direct G-protein interactions. Delta 9-tetrahydrocannibinol and related ligands likely exert their psychoactive effects by inhibiting presynaptic N- and P/Q type calcium channels. CB2 is thought to function primarily in the immune system although it has been suggested to be present in the central nervous system, including the retina.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Cannabinoid Receptor 2; cannabinoid receptor 2 (macrophage); CB-2; CB2 receptor; CB2R; CNR3; CX5; HCB2; HGNC:2160; OTTHUMP00000044841; peripheral cannabinoid receptor; rCB2; RP11-4M23.1; testis-dominant CNR2 isoform CB2
基因别名: CB-2; CB2; CB2A; CB2B; CB2C; CNR2; CNR2C; CX5
UniProt ID: (Human) P34972, (Rat) Q9QZN9
Entrez Gene ID: (Human) 1269, (Rat) 57302
response to amphetamine
inflammatory response
immune response
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
sensory perception of pain
negative regulation of synaptic transmission, GABAergic
response to lipopolysaccharide
negative regulation of mast cell activation
cannabinoid signaling pathway
negative regulation of action potential
negative regulation of inflammatory response
negative regulation of nitric-oxide synthase activity
G-protein coupled receptor signaling pathway
