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Invitrogen
CNR2 Recombinant Rabbit Monoclonal Antibody (13H43L20)
高级验证
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
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CNR2 Antibody (703485) in ICC/IF
HEK-293 cells transiently transfected with CNR2 were grown on poly-L-lysine-coated coverslips overnight. After 24 h, cells were fixed with 4% paraformaldehyde and 0.2% picric acid in phosphate buffer (pH 6.9) for 30 min at room temperature and washed several times with phosphate buffer. Specimens were permeabilized with ice-cold methanol and then incubated with Anti-CNR2 Recombinant Rabbit Monoclonal Antibody (Product # 703485, 1:500 dilution). Cells were then incubated with Alexa488-conjugated secondary antibody for 2 h at room temperatur... View More
产品信息
703485
产品规格
种属反应
Human,
Mouse
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
13H43L20
抗原
Peptides corresponding to human CNR2 [1) aa341-aa360, 2) aa5-aa25, 3) aa2-25]
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2895879
产品详细信息
This antibody is predicted to react with Rat, Bovine.
靶标信息
Cannabinoids exert their well known physiological effects through two G protein coupled receptors, cannabinoid receptor 1 (CB1) and CB2. Both cannabinoid receptors have been shown to inhibit adenylyl cyclase as well as stimulate the mitogen-activated protein kinase, MAPK. CB1 receptors also modulate ion channels through direct G-protein interactions. Delta 9-tetrahydrocannibinol and related ligands likely exert their psychoactive effects by inhibiting presynaptic N- and P/Q type calcium channels. CB2 is thought to function primarily in the immune system although it has been suggested to be present in the central nervous system, including the retina.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Cannabinoid Receptor 2; cannabinoid receptor 2 (macrophage); CB-2; CB2R; CNR3; CX5; HCB2; HGNC:2160; OTTHUMP00000044841; RP11-4M23.1; testis-dominant CNR2 isoform CB2
基因别名: CB-2; CB2; CB2-R; CB2A; CB2B; CNR2; CX5
UniProt ID: (Human) P34972, (Mouse) P47936
Entrez Gene ID: (Human) 1269, (Mouse) 12802
response to amphetamine
inflammatory response
immune response
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
sensory perception of pain
negative regulation of synaptic transmission, GABAergic
response to lipopolysaccharide
negative regulation of mast cell activation
cannabinoid signaling pathway
negative regulation of action potential
negative regulation of inflammatory response
negative regulation of nitric-oxide synthase activity
