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Abnova
COL25A1 Polyclonal Antibody, MaxPab™
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产品信息
H00084570-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
COL25A1 (AAH36669.1, 1 a.a. approximately 496 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MLLKKHAGKG GGREPRSEDP TPAEQHCART MPPCAVLAAL LSVVAVVSCL YLGVKTNDLQ ARIAALESAK GAPSIHLLPD TLDHLKTMVQ EKVERLLAQK SYEHMAKIRI AREAPSECNC PAGPPGKRGK RGRRGESGPP GQPGPQGPPG PKGDKGEQGD QGPRGPLGPP GQKGSIGAPG IPGMNGQKGE PGLPGAVGQN GIPGPKGEPG EQGEKGDAGE NGPKGDTGEK GDPGSSAAGI KGEPGESGRP GQKGEPGLPG LPGLPGIKGE PGFIGPQGEP GLPGLPGTKG ERGEAGPPGR GERGEPGAPG PKGKQGESGT RGPKGSKGDR GEKGDSGAQG PRGPPGQKGD QGATEIIDYN GNLHEALQRI TTLTVTGPPG PPGPQGLQGT KGEQGSPGIP GMDGEQGLKG SKGDMGDPGS QWNERRKRRF WNAGSTGSFY HRPTRPTRSP WPTWPHGTSW TSWTKGSIWL RRKARIPGYR WSYGTPWPCR SQRRKR
靶标信息
Alzheimer's disease (AD) is characterized by deposition of beta-amyloid as senile plaques and cerebral amyloid angiopathy. The principal component of AD amyloid is the amyloid beta peptide (A beta). Although production and deposition of A beta appear closely related to the pathogenesis of AD, current evidence suggest that A beta alone is not sufficient to cause neuronal death and symptoms of dementia. A component of senile plaque (SP), CLAC (collagen-like Alzheimer amyloid plaque component ) and its precursor CLAC-P are deposited with extracellular beta-amyloid and have been recently implicated in cell toxicity of beta-amyloid in AD brains. CLAC-P is a unique, membrane-bound collagen-like structure containing three Gly-X-Y repeat motifs and may define a novel class of neuronal collagens.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Alzheimer disease amyloid-associated protein; AMY; CLAC-P; Collagen alpha-1(XXV) chain; collagen-like Alzheimer amyloid plaque component; collagenous Alzheimer amyloid plaque component
基因别名: AMY; CFEOM5; CLAC; CLAC-P; CLACP; COL25A1
UniProt ID: (Human) Q9BXS0
Entrez Gene ID: (Human) 84570
