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| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫组化 (IHC) |
4-6 µg/mL | - |
免疫组化（石蜡） (IHC (P)) |
4-6 µg/mL | - |
免疫细胞化学 (ICC/IF) |
- | 查看1篇已发表文章 1篇已发表文章 |
| 产品规格 | |
|---|---|
种属反应 |
Human |
已发表种属 |
Human |
宿主/亚型 |
Goat / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Peptide with sequence C-RGPTEYYDTYQEK, from the internal region of COL4A3 (aa341-353) |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
0.5 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
TBS, pH 7.3, with 0.5% BSA |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2554462 |
This antibody is predicted to react with dog and cow based on sequence homology.
Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jun 2010].
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: collagen alpha-3; Collagen alpha-3(IV) chain; collagen IV, alpha-3 polypeptide; collagen, type IV, alpha 3 (Goodpasture antigen); Goodpasture antigen; IV chain; Tumstatin
基因别名: COL4A3
UniProt ID: (Human) Q01955
Entrez Gene ID: (Human) 1285
分子生物学功能:
extracellular matrix protein
extracellular matrix structural protein
