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Proteintech
COMT Polyclonal Antibody
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产品信息
14754-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
COMT Fusion Protein Ag6502 (90-271 aa encoded by BC000419)
偶联物
形式
Liquid
浓度
0.19 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MNVGDKKGK IVDAVIQEHQ PSVLLELGAY CGYSAVRMAR LLSPGARLIT IEINPDCAAI TQRMVDFAGM KDKVTLVVGA SQDIIPQLKK KYDVDTLDMV FLDHWKDRYL PDTLLLEECG LLRKGTVLLA DNVICPGAPD FLAHVRGSSC FECTHYQSFL EYREVVDGLE KAIYKGPGSE AGP (90-271 aa encoded by BC000419)
靶标信息
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Catechol O-methyltransferase; catechol-O-methyltransferase 1; catechol-O-methyltransferase isoform; catecholamine-O-methyltransferase; epididymis secretory sperm binding protein Li 98n; OTTHUMP00000197749; OTTHUMP00000197750; testicular tissue protein Li 42
基因别名: COMT; Comt1; D16Wsu103e; D330014B15Rik; HEL-S-98n
UniProt ID: (Human) P21964, (Mouse) O88587, (Rat) P22734
Entrez Gene ID: (Human) 1312, (Mouse) 12846, (Rat) 24267
female pregnancy
learning
short-term memory
estrogen metabolic process
response to organic cyclic compound
cellular response to phosphate starvation
methylation
response to lipopolysaccharide
developmental process
negative regulation of renal sodium excretion
neurotransmitter catabolic process
dopamine catabolic process
response to drug
negative regulation of dopamine metabolic process
response to pain
multicellular organismal reproductive process
negative regulation of smooth muscle cell proliferation
positive regulation of homocysteine metabolic process
regulation of sensory perception of pain
catecholamine metabolic process
catechol-containing compound metabolic process
dopamine metabolic process
S-adenosylhomocysteine metabolic process
S-adenosylmethionine metabolic process
