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Invitrogen
COP1 Polyclonal Antibody
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COP1 Antibody (PA5-141993) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of COP1 in U2OS cells using COP1 Polyclonal Antibody (Product # PA5-141993). Cells were fixed with paraformaldehyde, permeabilized with 0.15% Triton, and incubated with the primary antibody for 1hr (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing mitochondrial staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL).
产品信息
PA5-141993
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide with sequence C-ETLGLSAGPIPGN.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Additional Information: This antibody is expected to recognize isoform 2 (NP_443121.1) only. In addition there may be cross-reaction with INCA (GeneID 440068; NP_001007233.1).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:4,000.
靶标信息
Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CARD only domain-containing protein 1; CARD only protein; CARD-only protein 1; caspase recruitment domain family, member 16; Caspase recruitment domain-containing protein 16; Caspase recruitment domain-only protein 1; caspase-1 dominant-negative inhibitor pseudo-ICE; Caspase-1 inhibitor COP; Pseudo interleukin-1 beta converting enzyme; pseudo interleukin-1beta converting enzyme; Pseudo-ICE; pseudo-IL1B-converting enzyme
基因别名: CARD16; COP; COP1; PSEUDO-ICE
UniProt ID: (Human) Q5EG05
Entrez Gene ID: (Human) 114769
