Peptide Sequence: VMACGVTGSV SVALHPLVIL NISDHWIRMR SQEGRPVQVI GALIGKQEGR NIEVMNSFEL LSHTVEEKII IDKEYYYTKE EQFKQVFKEL EFLGWYTTGG PPDPSDIHVH KQVCEIIESP LFLKLNPMTK HTDLPVSVFE SVIDIINGEA TMLFAELTYT LATEEAERIG VDHVARMTAT GSGENSTVAE HLIAQHSAIK MLHSRVKLIL EYVKASEAGE VPFNHEILRE AYALCHCLPV LSTDKFKTDF YDQCN
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr.
蛋白别名: COP9 constitutive photomorphogenic homolog subunit 6; COP9 signalosome complex subunit 6; H_NH0506M12.12; hVIP; JAB1-containing signalosome subunit 6; MOV34 homolog; MOV34 homolog, 34 kD; SGN6; Vpr-interacting protein
基因别名: COPS6; CSN6; HVIP; MOV34-34KD
UniProt ID: (Human) Q7L5N1
Entrez Gene ID: (Human) 10980
分子生物学功能: translation initiation factor