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CORIN Antibody (711422) in IHC (F)
Immunofluorescence analysis of Corin in mouse heart tissue: Frozen sections were fixed with 4% PFA for 20 min, permeabilized using 0.1% Triton-X 100 for 10 mins and blocked for 1 hour with 2% BSA. Transverse sections of mouse heart atrium were incubated with Anti- Corin Recombinant Rabbit Polyclonal Antibody (Product # 711422, 2 µg/mL) overnight at 4°C, followed by Goat anti-Rabbit IgG (Heavy Chain) Supercl... View More
产品信息
711422
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Superclonal
类型
Antibody
抗原
Protein corresponding to human Corin [aa802-aa1042]
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2692253
产品详细信息
This antibody is predicted to react with Monkey, Cat, Horse
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
靶标信息
CORIN is a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. CORIN converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Atrial natriuretic peptide-converting enzyme; Corin; EC 3.4.21; Heart-specific serine proteinase ATC2; Low density lipoprotein receptor-related protein 4; low density lipoprotein-related protein 4; MGC119742; pro-ANP-convertase; Pro-ANP-converting enzyme; PRSC; serine peptidase; serine protease; Transmembrane protease serine 10
基因别名: ATC2; AV273130; CORIN; CRN; Lrp4; PEE5; TMPRSS10
UniProt ID: (Human) Q9Y5Q5, (Mouse) Q9Z319, (Rat) Q80YN4
Entrez Gene ID: (Human) 10699, (Mouse) 53419, (Rat) 289596
regulation of systemic arterial blood pressure by atrial natriuretic peptide
female pregnancy
regulation of blood pressure
peptide hormone processing
regulation of renal sodium excretion
regulation of cardiac conduction
proteolysis
protein processing
neuron differentiation
receptor-mediated endocytosis
