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Proteintech
COX4I2 Polyclonal Antibody
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产品信息
11463-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
COX4I2 Fusion Protein Ag1987 (1-171 aa encoded by BC057779)
偶联物
形式
Liquid
浓度
0.33 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This antibody was generated against full length COX4I2 protein.
Immunogen sequence: MLPRAAWSL VLRKGGGGRR GMHSSEGTTR GGGKMSPYTN CYAQRYYPMP EEPFCTELNA EEQALKEKEK GSWTQLTHAE KVALYRLQFN ETFAEMNRRS NEWKTVMGCV FFFIGFAALV IWWQRVYVFP PKPITLTDER KAQQLQRMLD MKVNPVQGLA SRWDYEKKQW KK (1-171 aa encoded by BC057779)
靶标信息
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunbit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. [Uniprot]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: COX IV-2; Cytochrome c oxidase subunit 4 isoform 2, mitochondrial; Cytochrome c oxidase subunit IV isoform 2; cytochrome c oxidase subunit IV isoform 2 (lung); cytochrome c oxidase subunit IV-like 2; cytochrome c oxidase, subunit 4b; cytochrome c oxidase, subunit IVb
基因别名: COX4; COX4-2; COX4B; COX4I2; COX4L2; COXIV-2; dJ857M17.2
UniProt ID: (Human) Q96KJ9, (Mouse) Q91W29, (Rat) Q91Y94
Entrez Gene ID: (Human) 84701, (Mouse) 84682, (Rat) 84683
