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Invitrogen
CPLX1/CPLX2 Polyclonal Antibody
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CPLX1/CPLX2 Antibody (PA5-111853) in WB
Western Blot analysis of CPLX1/2 was performed in mouse (lanes 1 and 3) and rat (lanes 2 and 4) brain lysates. Lane 1,2: CPLX1/CPLX2 Antibody (Product # PA5-111853) at a dilution of 1:200. Lane 3,4: CPLX1/CPLX2 Antibody preincubated with the negative control antigen.
产品信息
PA5-111853
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide corresponding to amino acid residues 14-27 of rat Complexin-1 (Intracellular, N-terminus)
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
保存条件
-20°C
运输条件
Wet ice
RRID
产品详细信息
Reconstitute antibody with 50 µL of double distilled water (DDW). The reconstituted solution can be stored at 4 degrees C for up to 1 week. For longer periods, small aliquots should be stored at -20 degrees C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Peptide sequence is: (C)KDMGKML GGDEEKD
Homology: Complexin 1: Mouse, human amino acid residues are identical.Complexin 2: Rat, mouse, human - 13/14 amino acid residues identical.
靶标信息
Complexins (1 through 4) are small cytosolic proteins that bind tightly to a complex of SNARE proteins to regulate synaptic vesicle membrane fusion via its interaction withsynaptotagmin. Complexins activate the quick release of neurotransmitters, triggered by calcium release. They also regulate the spontaneous release of neurotransmitters. Complexins are evolutionarily conserved in mammals, Drosophila, and Caenorhabditis elegans. They are divided into four structural domains: flexible N- and C-terminal domains, an accessory domain, and a central alpha-helical domain. The N-terminal domain plays a role in activation of fast synchronous release in murine neurons and in isolated chromaffin cells. The C-terminal domain binds to phospholipids and is important for regulating spontaneous release in neuronal cultures and suppressing Ca2+-independent fusion in vitro. The accessory domain is necessary for regulating spontaneous release and the central domain is required for all functions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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