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NeoBiotechnologies
CPS1/Carbamoyl-Phosphate Synthetase (Hepatocellular Marker) Recombinant Rabbit Monoclonal Antibody (CPS1/13326R)
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CPS1/Carbamoyl-Phosphate Synthetase (Hepatocellular Marker) Antibody (1373-RBM32-P1) in IHC (P)
Formalin-fixed, paraffin-embedded human hepatocellular carcinoma (HCC) stained with Carbamoyl-phosphate Synthetase (CPS1) Recombinant Rabbit Monoclonal Antibody (CPS1/13326R). Inset: PBS instead of primary antibody; secondary only negative control.
产品信息
1373-RBM32-P1
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
CPS1/13326R
抗原
Recombinant full-length human CPS1 protein.
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product cellular localization: Cytoplasm.
Positive control: Human Liver, Mouse Liver, Rat Liver, HeLa cells. Liver or Hepatocellular Carcinoma (HCC).
Tissue specificity: Primarily in the liver and small intestine.
靶标信息
The mitochondrial enzyme encoded by this gene catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells. The encoded protein may also represent a core mitochondrial nucleoid protein. Three transcript variants encoding different isoforms have been found for this gene. The shortest isoform may not be localized to the mitochondrion. Mutations in this gene have been associated with carbamoyl phosphate synthetase deficiency, susceptibility to persistent pulmonary hypertension, and susceptibility to venoocclusive disease after bone marrow transplantation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: carbamoyl-phosphate synthase (ammonia); carbamoyl-phosphate synthase 1, mitochondrial; Carbamoyl-phosphate synthase [ammonia], mitochondrial; carbamoyl-phosphate synthetase 1, mitochondrial; Carbamoyl-phosphate synthetase I; carbamoylphosphate synthetase I; carbamyl phosphate synthetase I; carboamyl-phosphate synthetase 1; CPSase I
基因别名: 4732433M03Rik; CPS; CPS1; CPSASE1; D1Ucla3; PHN
UniProt ID: (Human) P31327, (Mouse) Q8C196, (Rat) P07756
Entrez Gene ID: (Human) 1373, (Mouse) 227231, (Rat) 497840
aspartate carbamoyltransferase activity
carbamoyl-phosphate synthase (ammonia) activity
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
dihydroorotase activity
endopeptidase activity
calcium ion binding
protein binding
ATP binding
phospholipid binding
glutamate binding
protein complex binding
modified amino acid binding
nucleotide binding
catalytic activity
ligase activity
metal ion binding
ligase
urea cycle
glycogen catabolic process
'de novo' pyrimidine nucleobase biosynthetic process
proteolysis
arginine biosynthetic process
glutamine metabolic process
midgut development
response to toxic substance
response to zinc ion
response to amine
citrulline biosynthetic process
triglyceride catabolic process
response to food
response to lipopolysaccharide
response to drug
response to starvation
response to amino acid
cellular response to fibroblast growth factor stimulus
positive regulation of vasodilation
nitric oxide metabolic process
homocysteine metabolic process
anion homeostasis
response to growth hormone
hepatocyte differentiation
carbamoyl phosphate biosynthetic process
cellular response to cAMP
cellular response to glucagon stimulus
cellular response to oleic acid
response to dexamethasone
nitrogen compound metabolic process
metabolic process
liver development
glutamine catabolic process
response to glucagon
response to oleic acid
response to steroid hormone
response to glucocorticoid
response to cAMP
