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Proteintech
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Immunogen sequence: STNTPCARI PRMTGEEKEF ETIERDERYI HPQQEAFSIQ LISPVSWEAI PNARIELQEW EHVTCMKTVS LRSEETVSGL KGYVAAGTCL MQGEEVTCRG RILIMDVIEV VPEPGQPLTK NKFKVLYEKE QKGPVTALCH CNGHLVSAIG QKIFLWSLRA SELTGMAFID TQLYIHQMIS VKNFILAADV MKSISLLRYQ EESKTLSLVS RDAKPLEVYS VDFMVDNAQL GFLVSDRDRN LMVYMYLPEA KESFGGMRLL RRADFHVGAH VNTFWRTPCR GATEGLSKKS VVWENKHITW FATLDGGIGL LLPMQEKTYR RLLMLQNALT TMLPHHAGLN PRAFRMLHVD RRTLQNAVRN VLDGELLNRY LYLSTMERSE LAKKIGTTPD IILDDLLETD RVTAHF (1039-1443 aa encoded by BC017232)
Midline-1 (Tripartite motif-containing protein 18, Putative transcription factor XPRF, RING finger protein 59) is a 667 amino acid protein encoded by the human gene MID1. Midline-1 belongs to the TRIM/RBCC family and contains two B box-type zinc fingers, one B30.2/SPRY domain, one COS domain, one fibronectin type-III domain and one RING-type zinc finger. Midline-1 is believed to have E3 ubiquitin ligase activity which targets the catalytic subunit of protein phosphatase 2 for degradation. It is a cytoplasmic protein found as a homodimer or heterodimer with Midline-2. It also interacts with IGBP1 (Lymphocyte signaling protein A4). Defects in MID1 are the cause of Opitz syndrome type I (OS-I). OS-I is an X-linked recessive disorder characterized by hypertelorism, genital-urinary defects such as hypospadias in males and splayed labia in females, lip-palate-laryngotracheal clefts, imperforate anus, developmental delay and congenital heart defects.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: cleavage and polyadenylation specific factor 1, 160kDa; Cleavage and polyadenylation specificity factor 160 kDa subunit; Cleavage and polyadenylation specificity factor subunit 1; CPSF 160 kDa subunit; polyadenylation specificity factor
基因别名: CPSF1; CPSF160; HSU37012; P/cl.18
UniProt ID: (Human) Q10570
Entrez Gene ID: (Human) 29894