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Invitrogen
CPSF1 Polyclonal Antibody
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CPSF1 Antibody (PA5-116722) in WB
Western blot analysis of CPSF1 in extracts of various cell lines. Samples were incubated with CPSF1 Polyclonal antibody (Product # PA5-116722) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
产品信息
PA5-116722
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 700-950 of human CPSF1 (NP_0374232)
偶联物
形式
Liquid
浓度
1.65 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: 293T, NIH/3T3, Mouse liver
Immunogen sequence: LYRDLSGMFT TESRLGGARD ELGGRSGPEA EGLGSETSPT VDDEEEMLYG DSGSLFSPSK EEARRSSQPP ADRDPAPFRA EPTHWCLLVR ENGTMEIYQL PDWRLVFLVK NFPVGQRVLV DSSFGQPTTQ GEARREEATR QGELPLVKEV LLVALGSRQS RPYLLVHVDQ ELLIYEAFPH DSQLGQGNLK VRFKKVPHNI NFREKKPKPS KKKAEGGGAE EGAGARGRVA RFRYFEDIYG YSGVFICGPS P
靶标信息
Midline-1 (Tripartite motif-containing protein 18, Putative transcription factor XPRF, RING finger protein 59) is a 667 amino acid protein encoded by the human gene MID1. Midline-1 belongs to the TRIM/RBCC family and contains two B box-type zinc fingers, one B30.2/SPRY domain, one COS domain, one fibronectin type-III domain and one RING-type zinc finger. Midline-1 is believed to have E3 ubiquitin ligase activity which targets the catalytic subunit of protein phosphatase 2 for degradation. It is a cytoplasmic protein found as a homodimer or heterodimer with Midline-2. It also interacts with IGBP1 (Lymphocyte signaling protein A4). Defects in MID1 are the cause of Opitz syndrome type I (OS-I). OS-I is an X-linked recessive disorder characterized by hypertelorism, genital-urinary defects such as hypospadias in males and splayed labia in females, lip-palate-laryngotracheal clefts, imperforate anus, developmental delay and congenital heart defects.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cleavage and polyadenylation specific factor 1, 160kDa; cleavage and polyadenylation specificity factor 1; Cleavage and polyadenylation specificity factor 160 kDa subunit; Cleavage and polyadenylation specificity factor subunit 1; CPSF 160 kDa subunit; CPSF160; polyadenylation specificity factor
基因别名: CPSF1; CPSF160; HSU37012; P/cl.18
UniProt ID: (Human) Q10570, (Mouse) Q9EPU4
Entrez Gene ID: (Human) 29894, (Mouse) 94230
