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Proteintech
CREB3L1/OASIS Monoclonal Antibody (2B5B4), CoraLite® Plus 488
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产品信息
CL488-67617
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
2B5B4
抗原
Recombinant protein
偶联物
激发/发射光谱
493/522 nm
形式
Liquid
纯化类型
Protein G
保存液
PBS with 50% glycerol, 0.5% BSA
内含物
0.05% ProClin 300
保存条件
-20°C, store in dark
运输条件
Wet ice
产品详细信息
Immunogen sequence: PHQAPGEMTQ LPVIKAEPLE VNQFLKVTPE DLVQMPPTPP SSHGSDSDGS QSPRSLPPSS PVRPMARSST AISTSPLLTA PHKLQGTSGP LLLTEEEKRT LIAEGYPIPT KLPLTKAEEK ALKRVRRKIK NKISAQESRR KKKEYVECLE KKVETFTSEN NELWKKVETL ENANRTLLQQ LQKLQTLVTN KISRPYKMAA TQTGTCLMVA ALCFVLVLGS LVPCLPEFSS GSQTVKEDPL AADGVYTASQ MPSRSLLFYD DGAGLWEDGR STLLPMEPPD GWEINPGGPA EQRPRDHLQH DHLDSTHETT KYLSEAWPKD GGNGTSPDFS HSKEWFHDRD LGPNTTIKLS
靶标信息
Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system. May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BBF-2 homolog; cAMP responsive element binding protein 3-like 1; cAMP-responsive element-binding protein 3-like protein 1; Cyclic AMP-responsive element-binding protein 3-like protein 1; OASIS; old astrocyte specifically induced substance; Old astrocyte specifically-induced substance
基因别名: CREB3L1; OASIS; PSEC0238
UniProt ID: (Human) Q96BA8, (Mouse) Q9Z125, (Rat) Q66HA2
Entrez Gene ID: (Human) 90993, (Mouse) 26427, (Rat) 362165
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
protein binding
cAMP response element binding
sequence-specific DNA binding
transcription regulatory region DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
osteoblast differentiation
transcription from RNA polymerase II promoter
multicellular organism development
endoplasmic reticulum unfolded protein response
extracellular matrix constituent secretion
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
transcription, DNA-templated
regulation of transcription, DNA-templated
response to unfolded protein
regulation of ossification
positive regulation of transcription from RNA polymerase II promoter
regulation of bone mineralization
