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产品信息
MA5-18655
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
1-5 µg/mL | - |
酶联免疫吸附实验 (ELISA) |
Assay-Dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Mouse / IgG1, kappa |
分类 |
Monoclonal |
类型 |
Antibody |
克隆号 |
2H3 |
抗原 |
CRYGD (NP_008822, 75 a.a. ~ 174 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
0.2-1.0 mg/mL |
纯化类型 |
Affinity chromatography |
保存液 |
PBS, pH 7.4 |
内含物 |
no preservative |
保存条件 |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2609656 |
产品详细信息
Peptide Sequence: SVRSCRLIPH SGSHRIRLYE REDYRGQMIE FTEDCSCLQD RFRFNEIHSL NVLEGSWVLY ELSNYRGRQY LLMPGDYRRY QDWGATNARV GSLRRVIDFS
靶标信息
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Beta4abc; crystallin, gamma D; gamma crystallin 4; Gamma crystallin D; Gamma D crystallin; Gamma-crystallin 4; Gamma-crystallin D; Gamma-D-crystallin
基因别名: CACA; CCA3; CCP; cry-g-D; CRYG4; CRYGD; CTRCT4; PCC
UniProt ID: (Human) P07320
Entrez Gene ID: (Human) 1421
