Abnova

CSF1 Polyclonal Antibody, MaxPab™

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说明书
实验方案
问题与答案
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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
CSF1 Polyclonal Antibody, MaxPab™

产品信息

H00001435-D01P

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1-5 µg/mL
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

CSF1 (NP_000748.3, 1 a.a. approximately 554 a.a) full-length human protein.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

See Label

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Sequence of this protein is as follows: MTAPGAAGRC PPTTWLGSLL LLVCLLASRS ITEEVSEYCS HMIGSGHLQS LQRLIDSQME TSCQITFEFV DQEQLKDPVC YLKKAFLLVQ DIMEDTMRFR DNTPNAIAIV QLQELSLRLK SCFTKDYEEH DKACVRTFYE TPLQLLEKVK NVFNETKNLL DKDWNIFSKN CNNSFAECSS QDVVTKPDCN CLYPKAIPSS DPASVSPHQP LAPSMAPVAG LTWEDSEGTE GSSLLPGEQP LHTVDPGSAK QRPPRSTCQS FEPPETPVVK DSTIGGSPQP RPSVGAFNPG MEDILDSAMG TNWVPEEASG EASEIPVPQG TELSPSRPGG GSMQTEPARP SNFLSASSPL PASAKGQQPA DVTGTALPRV GPVRPTGQDW NHTPQKTDHP SALLRDPPEP GSPRISSLRP QGLSNPSTLS AQPQLSRSHS SGSVLPLGEL EGRRSTRDRR SPAEPEGGPA SEGAARPLPR FNSVPLTDTG HERQSEGSSS PQLQESVFHL LVPSVILVLL AVGGLLFYRW RRRSHQEPQR ADSPLEQPEG SPLTQDDRQV ELPV

靶标信息

M-CSF (Macrophage colony-stimulating factor, CSF-1) is a survival factor essential for the proliferation and development of monocytes, macrophages, and osteoclast progenitor cells. M-CSF also induces VEGF (vascular endothelial growth factor) secretion by macrophages, thereby mediating mobilization of endothelial progenitor cells and neovascularization. M-CSF is present as several bioactive isoforms that differ in potency and stability. The full-length protein is synthesized as a membrane-spanning protein that can be expressed on the cell surface or further cleaved and modified in the secretory vesicle. Further, M-CSF is a disulfide-bonded homodimer which is processed into one of two isoforms, a glycoprotein or a proteoglycan that has been modified by the addition of chondroitin sulfate to each subunit. Binding of M-CSF to its receptor, c-Fms (CSF-1R or CD115) induces dimerization of the receptor followed by internalization and degradation of the complex. Functionally, M-CSF is known to stimulate differentiation of hematopoietic stem cells to monocyte-macrophage cell populations in culture. M-CSF acts through the CSF receptor 1. Although human M-CSF shows activity on mouse cells, mouse CSF shows no activity on human cells.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: colony stimulating factor 1 (macrophage); CSF-1; H-MCSF; Lanimostim; M-MCSF; macrophage colony stimulating factor 1; Macrophage colony-stimulating factor 1; MGC31930; PG-M-CSF; Proteoglycan macrophage colony-stimulating factor

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基因别名: CSF-1; CSF1; MCSF

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UniProt ID: (Human) P09603

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Entrez Gene ID: (Human) 1435

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功能
cytokine activity macrophage colony-stimulating factor receptor binding protein binding growth factor activity protein homodimerization activity
参与通路
ossification positive regulation of cell-matrix adhesion osteoclast proliferation developmental process involved in reproduction inflammatory response transmembrane receptor protein tyrosine kinase signaling pathway cell proliferation positive regulation of cell proliferation positive regulation of gene expression regulation of macrophage derived foam cell differentiation positive regulation of macrophage derived foam cell differentiation positive regulation of macrophage chemotaxis hemopoiesis cell differentiation macrophage differentiation regulation of ossification osteoclast differentiation positive regulation of cell migration positive regulation of cellular protein metabolic process positive regulation of mononuclear cell proliferation macrophage colony-stimulating factor signaling pathway positive regulation of multicellular organism growth monocyte activation odontogenesis positive regulation of odontogenesis of dentin-containing tooth innate immune response positive regulation of macrophage differentiation positive regulation of monocyte differentiation positive regulation of osteoclast differentiation positive regulation of protein kinase activity positive regulation of Ras protein signal transduction homeostasis of number of cells within a tissue branching involved in mammary gland duct morphogenesis mammary gland fat development mammary duct terminal end bud growth positive regulation of macrophage colony-stimulating factor signaling pathway positive regulation of microglial cell migration
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