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Abnova
CSF1 Monoclonal Antibody (1A9)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00001435-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
1A9
抗原
CSF1 (AAH21117, 33 a.a. approximately 132 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.35 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
Immunogen sequence: EEVSEYCSHM IGSGHLQSLQ RLIDSQMETS CQITFEFVDQ EQLKDPVCYL KKAFLLVQDI MEDTMRFRDN TPNAIAIVQL QELSLRLKSC FTKDYEEHDK
靶标信息
M-CSF (Macrophage colony-stimulating factor, CSF-1) is a survival factor essential for the proliferation and development of monocytes, macrophages, and osteoclast progenitor cells. M-CSF also induces VEGF (vascular endothelial growth factor) secretion by macrophages, thereby mediating mobilization of endothelial progenitor cells and neovascularization. M-CSF is present as several bioactive isoforms that differ in potency and stability. The full-length protein is synthesized as a membrane-spanning protein that can be expressed on the cell surface or further cleaved and modified in the secretory vesicle. Further, M-CSF is a disulfide-bonded homodimer which is processed into one of two isoforms, a glycoprotein or a proteoglycan that has been modified by the addition of chondroitin sulfate to each subunit. Binding of M-CSF to its receptor, c-Fms (CSF-1R or CD115) induces dimerization of the receptor followed by internalization and degradation of the complex. Functionally, M-CSF is known to stimulate differentiation of hematopoietic stem cells to monocyte-macrophage cell populations in culture. M-CSF acts through the CSF receptor 1. Although human M-CSF shows activity on mouse cells, mouse CSF shows no activity on human cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: a secreted cytokine that influences hemopoietic stem cells to differentiate into macrophages or other related cell types; produced by eukaryotic cells in order to combat intercellular viral infection; binds to the colony-stimulating factor 1 receptor; may ; colony stimulating factor 1 (macrophage); colony-stimulating factor (CSF-1) precursor; CSF1-hERV-LTR71B fusion protein; H-MCSF; lanimostim; M-MCSF; macrophage colony stimulating factor 1; MGC31930; proteoglycan macrophage colony-stimulating factor; unnamed protein product
基因别名: CSF-1; MCSF; PG-M-CSF
UniProt ID: (Human) P09603
Entrez Gene ID: (Human) 1435
positive regulation of cell-matrix adhesion
positive regulation of immune system process
response to ischemia
developmental process involved in reproduction
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cell proliferation
positive regulation of gene expression
regulation of macrophage derived foam cell differentiation
positive regulation of macrophage derived foam cell differentiation
positive regulation of macrophage chemotaxis
macrophage differentiation
osteoclast differentiation
positive regulation of cell migration
positive regulation of mononuclear cell proliferation
macrophage colony-stimulating factor signaling pathway
monocyte activation
innate immune response
positive regulation of macrophage differentiation
positive regulation of monocyte differentiation
positive regulation of osteoclast differentiation
positive regulation of protein metabolic process
microglial cell proliferation
positive regulation of macrophage colony-stimulating factor signaling pathway
positive regulation of microglial cell migration
positive regulation of macrophage migration
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