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CSK Antibody (MA5-42618) in IHC (P)
Immunohistochemistry analysis of CSK in paraffin-embedded human lung cancer. Samples were incubated with CSK Monoclonal antibody (Product # MA5-42618) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
产品信息
MA5-42618
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
1A2F5
抗原
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CSK (P41240).
偶联物
形式
Liquid
浓度
0.51 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2911759
产品详细信息
Positive test controls include: A-549, Jurkat, Raji, C6, Mouse spleen, Mouse thymus, Rat lung, Rat spleen. The target is usually found in the following locations: Cell membrane, Cytoplasm.
Immunogen sequence: MSAIQAAWPS GTECIAKYNF HGTAEQDLPF CKGDVLTIVA VTKDPNWYKA KNKVGREGII PANYVQKREG VKAGTKLSLM PWFHGKITRE QAERLLYPPE
靶标信息
CSK is a tyrosine kinase that has been shown to downregulate the activity of SRC oncoprotein through phosphorylation of its carboxy terminus. Since cell transformation by SRC is caused by various mechanisms that interfere with this phosphorylation, the CSK gene might function as an antioncogene. CSK plays an important role in the regulation of cell growth, differentiation, migration, and immune responses. CSK phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases including LCK, SRC, HCK, FYN, LYN, CSK, and YES1. CSK is expressed ubiquitously as a protein of approximately 50 KDa in cytosol, but a fraction distributes to lipid rafts due to interaction with the lipid raft-associated protein PAG (Csk-binding protein).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-SRC kinase; MGC117393; p50CSK; protein-tyrosine kinase (CSK); Protein-tyrosine kinase CYL; Protein-tyrosine kinase MPK-2; Tyrosine-protein kinase CSK
基因别名: AW212630; CSK; p50CSK
UniProt ID: (Human) P41240, (Rat) P32577, (Mouse) P41241
Entrez Gene ID: (Human) 1445, (Rat) 315707, (Mouse) 12988
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
protein binding
ATP binding
protein C-terminus binding
kinase activity
protein phosphatase binding
protein kinase A catalytic subunit binding
identical protein binding
metal ion binding
proline-rich region binding
morphogenesis of an epithelium
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
brain development
negative regulation of cell proliferation
negative regulation of low-density lipoprotein particle clearance
cell migration
negative regulation of interleukin-6 production
negative regulation of kinase activity
adherens junction organization
peptidyl-tyrosine autophosphorylation
negative regulation of Golgi to plasma membrane protein transport
positive regulation of MAP kinase activity
innate immune response
negative regulation of bone resorption
protein autophosphorylation
oligodendrocyte differentiation
negative regulation of phagocytosis
regulation of Fc receptor mediated stimulatory signaling pathway
negative regulation of ERK1 and ERK2 cascade
cellular response to peptide hormone stimulus
regulation of cytokine production
adaptive immune response
epidermal growth factor receptor signaling pathway
central nervous system development
cell differentiation
T cell costimulation
regulation of cell proliferation
T cell receptor signaling pathway
