Invitrogen

CSK Monoclonal Antibody (CSK-04)

查看其他20个CSK抗体

Product Image Gallery

CSK Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of Csk in HeLa cells using a Csk monoclonal antibody (Product # MA1-34816). Actin was stained using a phalloidin (red) and cell nuclei were stained with DAPI (blue).

CSK Antibody in Western Blot (WB) — Western blot analysis of Csk using EL-4 mouse cell lysate. Samples were probed with a Csk monoclonal antibody (Product # MA1-34816) at a dilution of 1:250.

产品细节

Applications

Tested Dilution

Publications

免疫印迹 (WB)

1:250-1:300

-

免疫细胞化学 (ICC/IF)

Assay-dependent

-

免疫沉淀 (IP)

Assay-dependent

-

产品规格

种属反应

Human, Mouse

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

CSK-04

抗原

Recombinant fragment: VSDFGLTKEAS STQDTGKLPV KWTAPEALRE KKFSTKSDVW SFGILLWEIY SFGRVPYPRI PLKDVVPRVE KGYKMDAPDG CPPAVYEVMK NCWHLDAAMR PSFLQLREQL EHIKTHELHL, corresponding to amino acids 330-450 of Human CSK.

偶联物

Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

15mM sodium azide

保存条件

4° C

RRID

AB_1955628

产品详细信息

MA1-34816 detects CSK from human, mouse samples.

靶标信息

C-terminal Src kinase (CSK) is a non-receptor protein tyrosine kinase that plays an important role in the regulation of cell growth, differentiation, migration, and immune responses. CSK phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases including LCK, SRC, HCK, FYN, LYN, CSK, and YES1. CSK is expressed ubiquitously as a protein of approximately 50 KDa in cytosol, but a fraction distributes to lipid rafts due to interaction with the lipid raft-associated protein PAG (Csk-binding protein).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

引用文献 (0)

Have you cited this product in a publication?

Let us know so we can reference it here.

Cite this product

生物信息学

蛋白别名: C-Src kinase; MGC117393; p50CSK; Protein-tyrosine kinase CYL; Protein-tyrosine kinase MPK-2; Tyrosine-protein kinase CSK

基因别名: AW212630; CSK; p50CSK

UniProt ID: (Human) P41240, (Mouse) P41241

Entrez Gene ID: (Human) 1445, (Mouse) 12988

regulation of cytokine production adaptive immune response protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway epidermal growth factor receptor signaling pathway central nervous system development brain development negative regulation of cell proliferation negative regulation of low-density lipoprotein particle clearance cell migration cell differentiation T cell costimulation negative regulation of interleukin-6 production negative regulation of kinase activity adherens junction organization peptidyl-tyrosine autophosphorylation regulation of cell proliferation negative regulation of Golgi to plasma membrane protein transport positive regulation of MAP kinase activity innate immune response negative regulation of bone resorption oligodendrocyte differentiation negative regulation of phagocytosis T cell receptor signaling pathway regulation of Fc receptor mediated stimulatory signaling pathway negative regulation of ERK1 and ERK2 cascade cellular response to peptide hormone stimulus

参与通路

protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding protein binding ATP binding protein C-terminus binding kinase activity protein phosphatase binding protein kinase A catalytic subunit binding identical protein binding metal ion binding proline-rich region binding