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Proteintech
CSN2 Polyclonal Antibody, CoraLite® Plus 488
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产品信息
CL488-10969
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CSN2 fusion protein Ag1415
偶联物
激发/发射光谱
493/522 nm
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C, store in dark
运输条件
Wet ice
产品详细信息
Immunogen sequence: MSDMEDDFM CDDEEDYDLE YSEDSNSEPN VDLENQYYNS KALKEDDPKA ALSSFQKVLE LEGEKGEWGF KALKQMIKIN FKLTNFPEMM NRYKQLLTYI RSAVTRNYSE KSINSILDYI STSKQMDLLQ EFYETTLEAL KDAKNDRLWF KTNTKLGKLY LEREEYGKLQ KILRQLHQSC QTDDGEDDLK KGTQLLEIYA LEIQMYTAQK NNKKLKALYE QSLHIKSAIP HPLIMGVIRE CGGKMHLREG EFEKAHTDFF EAFKNYDESG SPRRTTCLKY LVLANMLMKS GINPFDSQEA KPYKNDPEIL AMTNLVSAYQ NNDITEFEKI LKTNHSNIMD DPFIREHIEE LLRNIRTQVL IKLIKPYTRI HIPFISKELN IDVADVESLL VQCILDNTIH GRIDQVNQLL ELDHQKRGGA RYTALDKWTN QLNSLNQAVV SKLA
靶标信息
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Alien homolog; alien-like; COP9; COP9 constitutive photomorphogenic homolog subunit 2; COP9 signalosome complex subunit 2; JAB1-containing signalosome subunit 2; SGN2; signalosome subunit 2; thyroid receptor interacting protein 15; Thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP-15
基因别名: AI315723; ALIEN; C85265; COPS2; CSN2; SGN2; TRIP-15; TRIP15
UniProt ID: (Human) P61201, (Mouse) P61202
Entrez Gene ID: (Human) 9318, (Mouse) 12848
negative regulation of transcription from RNA polymerase II promoter
nucleotide-excision repair, DNA damage recognition
transcription-coupled nucleotide-excision repair
transcription from RNA polymerase II promoter
signal transduction
cell proliferation
cullin deneddylation
neuron differentiation
skeletal muscle cell differentiation
negative regulation of nucleic acid-templated transcription
negative regulation of transcription, DNA-templated
