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Proteintech
CUL2 Polyclonal Antibody
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产品信息
10981-2-AP
应用
建议稀释比
已发表文章
产品规格
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CUL2 Fusion Protein Ag1434 (341-745 aa encoded by BC009591)
偶联物
形式
Liquid
浓度
0.13 mg/mL
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: ESVLEVHGK FVQLINTVLN GDQHFMSALD KALTSVVNYR EPKSVCKAPE LLAKYCDNLL KKSAKGMTEN EVEDRLTSFI TVFKYIDDKD VFQKFYARML AKRLIHGLSM SMDSEEAMIN KLKQACGYEF TSKLHRMYTD MSVSADLNNK FNNFIKNQDT VIDLGISFQI YVLQAGAWPL TQAPSSTFAI PQELEKSVQM FELFYSQHFS GRKLTWLHYL CTGEVKMNYL GKPYVAMVTT YQMAVLLAFN NSETVSYKEL QDSTQMNEKE LTKTIKSLLD VKMINHDSEK EDIDAESSFS LNMNFSSKRT KFKITTSMQK DTPQEMEQTR SAVDEDRKMY LQAAIVRIMK ARKVLRHNAL IQEVISQSRA RFNPSISMIK KCIEVLIDKQ YIERSQASAD EYSYVA (341-745 aa encoded by BC009591)
靶标信息
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
