Proteintech

CUL4B Monoclonal Antibody (4E10B10)

Name: CUL4B Monoclonal Antibody (4E10B10)
Brand: Proteintech
SKU: 60151-1-IG

8 篇参考文献

查看其他15个Cullin 4B抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (7)

CUL4B Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 7

CUL4B Antibody (60151-1-IG) in IHC (P)

Immunohistochemistry of paraffin-embedded human gliomas tissue slide using 60151-1-IG ( CUL4B Antibody) at dilution of 1:100 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

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Immunogen image

Immunogen Image CUL4B Monoclonal Antibody (4E10B10)

产品信息

60151-1-IG

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:4,000

查看3篇已发表文章 3篇已发表文章

免疫组化 (IHC)

查看1篇已发表文章 1篇已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:500

其他PubMed (Misc)

查看2篇已发表文章 2篇已发表文章

不适用 (N/A)

查看2篇已发表文章 2篇已发表文章

产品规格

种属反应

Human, Rat

已发表种属

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

4E10B10

抗原

CUL4B Fusion Protein Ag3563 (1-351 aa encoded by BC036216)

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Caprylic acid precipitation

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MMSQSSGSG DGNDDEATTS KDGGFSSPSP SAAAAAQEVR SATDGNTSTT PPTSAKKRKL NSSSSSSSNS SNEREDFDST SSSSSTPPLQ PRDSASPSTS SFCLGVSVAA SSHVPIQKKL RFEDTLEFVG FDAKMAEESS SSSSSSSPTA ATSQQQQLKN KSILISSVAS VHHANGLAKS STTVSSFANS KPGSAKKLVI KNFKDKPKLP ENYTDETWQK LKEAVEAIQN STSIKYNLEE LYQAVENLCS YKISANLYKQ LRQICEDHIK AQIHQFREDS LDSVLFLKKI DRCWQNHCRQ MIMIRSIFLF LDRTYVLQNS MLPSIWDMGL ELFRAHIISD QKVQNKTIDG IL (1-351 aa encoded by BC036216)

靶标信息

Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8.

仅用于科研。不用于诊断过程。未经明确授权不得转售。