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Invitrogen
CX3CR1/Albumin VHH-VHH-His Recombinant Alpaca Monoclonal Antibody (BI 655088)
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产品信息
MA562791
产品规格
种属反应
Human
宿主/亚型
Alpaca
/ VHH
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
BI 655088
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Metal-chelate chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
CX3CR1 also known as chemokine receptor 1 or fractalkine receptor is a G-protein-coupled receptor primarily expressed on subsets of immune cells such as monocytes natural killer cells and T lymphocytes. It binds to the chemokine ligand CX3CL1 (fractalkine) which is unique due to its membrane-bound nature and participates in critical processes like leukocyte adhesion and migration. This receptor-ligand interaction is vital for immune surveillance inflammation and tissue repair. Dysregulation of CX3CR1 is linked to various pathological states including chronic inflammatory diseases and cancer metastasis. In research contexts CX3CR1 is studied for its role in neuroinflammation and cardiovascular diseases where its modulation could offer therapeutic benefits. Albumin on the other hand is a versatile protein found in blood plasma and is the most abundant protein in human serum. It is crucial for maintaining osmotic pressure and acts as a carrier molecule for numerous endogenous and exogenous substances including hormones vitamins and drugs. Albumin's ability to bind and transport various molecules makes it an essential player in drug delivery systems and it is widely used in formulations to enhance the pharmacokinetics and bioavailability of therapeutic agents. The interaction between albumin and other drug molecules is a significant factor in pharmacology influencing drug distribution and clearance from the body.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Beta chemokine receptor-like 1; C-X3-C CKR-1; chemokine (C-C) receptor-like 1; chemokine (C-X3-C motif) receptor 1; chemokine (C-X3-C) receptor 1; Chemokine receptor 1; CMK-BRL-1; CMK-BRL1; CX3C chemokine receptor 1; Fractalkine receptor; G protein-coupled receptor 13; G-protein coupled receptor 13; Human albumin; Serum albumin; V28
基因别名: CCRL1; CMKBRL1; CMKDR1; CX3CR1; GPR13; GPRV28; V28
UniProt ID: (Human) P49238
Entrez Gene ID: (Human) 1524
positive regulation of neuroblast proliferation
microglial cell activation involved in immune response
negative regulation of chronic inflammatory response to non-antigenic stimulus
chemotaxis
cellular defense response
cell adhesion
G-protein coupled receptor signaling pathway
memory
response to wounding
viral process
negative regulation of angiogenesis
cerebral cortex cell migration
negative regulation of cell migration
positive regulation of angiogenesis
macrophage chemotaxis
chemokine-mediated signaling pathway
cellular response to lipopolysaccharide
cellular response to transforming growth factor beta stimulus
negative regulation of long-term synaptic potentiation
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
