Proteintech

CYFIP1/2 Polyclonal Antibody

Name: CYFIP1\/2 Polyclonal Antibody
Brand: Proteintech
SKU: 16011-1-AP

1 篇参考文献

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (7)

CYFIP1/2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 7

CYFIP1/2 Antibody (16011-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human gliomas tissue slide using 16011-1-AP (CYFIP1/2 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

CYFIP1/2 Antibody in Immunoprecipitation (IP)

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Immunogen image

Immunogen Image CYFIP1/2 Polyclonal Antibody

产品信息

16011-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

查看1篇已发表文章 1篇已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:500

免疫沉淀 (IP)

0.5-4.0 µg

产品规格

种属反应

Human, Mouse

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

CYFIP1/2 Fusion Protein Ag8749 (879-1278 aa encoded by BC011762)

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.19 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

This antibody can recognize both CYFIP1 and CYFIP2.

Immunogen sequence: CYNGSTNRF VRTAIPFTQE PQRDKPANVQ PYYLYGSKPL NIAYSHIYSS YRNFVGPPHF KTICRLLGYQ GIAVVMEELL KIVKSLLQGT ILQYVKTLIE VMPKICRLPR HEYGSPGILE FFHHQLKDII EYAELKTDVF QSLREVGNAI LFCLLIEQAL SQEEVCDLLH AAPFQNILPR VYIKEGERLE VRMKRLEAKY APLHLVPLIE RLGTPQQIAI AREGDLLTKE RLCCGLSMFE VILTRIRSYL QDPIWRGPPP TNGVMHVDEC VEFHRLWSAM QFVYCIPVGT NEFTAEQCFG DGLNWAGCSI IVLLGQQRRF DLFDFCYHLL KVQRQDGKDE IIKNVPLKKM ADRIRKYQIL NNEVFAILNK YMKSVETDSS TVEHVRCFQP PIHQSLATTC (879-1278 aa encoded by BC011762)

靶标信息

CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1, 278 amino acid protein encoded by the human gene CYFIP2. CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1. Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: CYFIP1; CYFIP2; Cytoplasmic FMR1-interacting protein 1; Cytoplasmic FMR1-interacting protein 2; cytoplasmic FMRP interacting protein 1; p140sra-1; p53-inducible protein 121; selective hybridizing clone; Specifically Rac1-associated protein 1; Sra-1

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基因别名: 1500004I01Rik; 6430511D02Rik; AA930218; AU022376; CYFIP1; CYFIP2; E030028J09Rik; KIAA0068; KIAA1168; l(7)1Rl; l71Rl; l7Rl1; mKIAA0068; mKIAA1168; P140SRA-1; P140sra1; PIR121; pl-1; SHYC; SRA-1; SRA1