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产品信息
PA5-50388
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
1:500-1:2,000 | - |
免疫组化（石蜡） (IHC (P)) |
1:50-1:200 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human, Mouse |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Fusion protein corresponding to residues near the C terminal of human cytoplasmic FMR1 interacting protein 2 |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1.2 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.4, with 40% glycerol |
内含物 |
0.05% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2635841 |
产品详细信息
The antibody detects endogenous levels of total CYFIP2 / PIR121 protein.
靶标信息
CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1,278 amino acid protein encoded by the human gene CYFIP2. CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1. Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CYFIP2; Cytoplasmic FMR1-interacting protein 2; p53-inducible protein 121
基因别名: 1500004I01Rik; 6430511D02Rik; AA930218; AU022376; CYFIP2; KIAA1168; mKIAA1168; PIR121
UniProt ID: (Human) Q53EN5, (Mouse) Q5SQX6
Entrez Gene ID: (Human) 26999, (Mouse) 76884
分子生物学功能:
scaffold/adaptor protein
