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MA3-033 detects Cytochrome P450 3A5 from HEK293 and HepG2 human cell lines, and from bovine liver and pancreas samples.
MA3-033 has been successfully used in Western blot applications. By Western blot, this antibody detects a ~54 kDa band representing Cytochrome P450 3A5.
The MA3-033 immunogen is a synthetic peptide corresponding to residues E S R D G T L S G E, conjugated to ovalbumin.
CYP3A5 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: aryl hydrocarbon hydroxylase; CYPIIIA28; CYPIIIA5; Cytochrome P450 3A5; cytochrome P450 HLp2; cytochrome P450, family 3, subfamily A, polypeptide 5; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5; Cytochrome P450-PCN3; flavoprotein-linked monooxygenase; HLp2; microsomal monooxygenase; P450-PCN3; xenobiotic monooxygenase
基因别名: CP35; CYP3A28; CYP3A4; CYP3A5; CYPIIIA5; P450PCN3; PCN3
UniProt ID: (Human) P20815
Entrez Gene ID: (Bovine) 282214, (Bovine) 526682, (Human) 1577
分子生物学功能: oxygenase