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Invitrogen
CYP3A7 Polyclonal Antibody
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CYP3A7 Antibody (PA5-120066) in WB
Western blot analysis of CYP3A7 in extracts of various cell lines. Samples were incubated with CYP3A7 Polyclonal antibody (Product # PA5-120066) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.
产品信息
PA5-120066
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 244-503 of human CYP3A7 (NP_000756.3).
偶联物
形式
Liquid
浓度
0.94 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive test controls include: A-549, HT-29, Mouse liver, Mouse lung, Rat liver. The target is usually found in the following locations: Endoplasmic reticulum membrane, Microsome membrane, Peripheral membrane protein.
Immunogen sequence: KVISFLTKSV KQIKEGRLKE TQKHRVDFLQ LMIDSQNSKD SETHKALSDL ELMAQSIIFI FAGYETTSSV LSFIIYELAT HPDVQQKVQK EIDTVLPNKA PPTYDTVLQL EYLDMVVNET LRLFPVAMRL ERVCKKDVEI NGMFIPKGVV VMIPSYVLHH DPKYWTEPEK FLPERFSKKN KDNIDPYIYT PFGSGPRNCI GMRFALVNMK LALVRVLQNF SFKPCKETQI PLKLRFGGLL LTEKPIVLKA ESRDETVSGA
靶标信息
This gene, CYP3A7, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. The enzyme also metabolizes some drugs such as aflatoxin B1. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Transcript variants have been described, but it is not known whether these transcripts are normally produced.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: aryl hydrocarbon hydroxylase; CYPIIIA7; Cytochrome P450 3A7; cytochrome P450, family 3, subfamily A, polypeptide 7; cytochrome P450, subfamily IIIA, polypeptide 7; Cytochrome P450-HFLA; flavoprotein-linked monooxygenase; microsomal monooxygenase; P450HLp2; xenobiotic monooxygenase
基因别名: CP37; CYP3A7; CYPIIIA7; P-450(HFL33); P-450111A7; P450-HFLA
UniProt ID: (Human) P24462
Entrez Gene ID: (Human) 1551
