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Invitrogen
CYP4F2 Polyclonal Antibody
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CYP4F2 Antibody (PA5-87655) in WB
Western blot analysis of CYP4F2 in extracts of various cell lines. Samples were incubated with CYP4F2 Polyclonal antibody (Product # PA5-87655) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-87655
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 40-120 of human CYP4F2 (NP_0010733)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
2.14 mg/mL
规格
214 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: AFYDNCRRLR CFPQPPRRNW FWGHQGMVNP TEEGMRVLTQ LVATYPQGFK VWMGPISPLL SLCHPDIIRS VINASAAIAP K; Positive Samples: LO2, HepG2, 293T; Cellular Location: Endoplasmic reticulum membrane, Microsome membrane, Peripheral membrane protein
靶标信息
CYP4F isoforms are involved in the oxidation of important cellular mediators, such as leukotriene B4 (LTB4) and prostaglandins. CYP4F2 catalyzes omega-hydroxylation of LTB4 to a less potent proinflammatory eicosanoid, 20-OH-LTB4 as well as arachidonic acid. CYP4F2 is expressed in liver and kidney. Its expression is repressed by peroxisomal proliferators and induced by retinoic acid. X-linked adrenoleukodystrophy (X-ALD) is a severe neurodegenerative disorder biochemically characterized by elevated levels of very long-chain fatty acids (VLCFA). CYP4F2 participates in the omega-hydroxylation of VLCFAs, which may provide an alternative mode of treatment for X-ALD patients.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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