Invitrogen

Calcitonin Monoclonal Antibody (SP17)

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Calcitonin Antibody in Immunohistochemistry (IHC) — Immunohistochemical analysis of Calcitonin using anti-Calcitonin Monoclonal Antibody (Product # MA5-16325) in Thyroid Medullary Tissue. The recommened dilution for this antibody in immunohistochemistry applications is 1:100.

产品信息

MA5-16325

应用	建议稀释比	已发表文章
免疫组化 (IHC)	-	查看3篇已发表文章 3篇已发表文章
免疫组化（石蜡） (IHC (P))	1:100	-
免疫细胞化学 (ICC/IF)	1:50	查看1篇已发表文章 1篇已发表文章

产品规格
种属反应	Human
已发表种属	Human, Rat
宿主/亚型	Rabbit / IgG
分类	Monoclonal
类型	Antibody
克隆号	SP17
抗原	Synthetic human calcitonin 1-32 amino acid peptide.
偶联物	Unconjugated
形式	Liquid
浓度	Conc. Not Determined
纯化类型	Protein A
保存液	PBS, pH 7.2, with 1% BSA
内含物	0.1% sodium azide
保存条件	-20° C, Avoid Freeze/Thaw Cycles
RRID	AB_2537844

产品详细信息

A suggested positive control is thyroid medullary carcinoma.

靶标信息

Calcitonin is a 32 amino acid peptide which can be demonstrated in C cells of the normal and hyperplastic thyroid. Staining for calcitonin may be used for the identification of a spectrum of C cell proliferative abnormalities ranging from C cell hyperplasia to invasive tumors. Staining for calcitonin in medullary carcinoma of the thyroid produces a fine granular pattern in the cytoplasm. Amyloid deposits within the tumor may also exhibit varying degrees of calcitonin activity.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Thyroid Paraganglioma Diagnosed by Fine-Needle Aspiration Biopsy, Correlated With Histopathological Findings: Report of a Case.

Diagnostic cytopathology

Çetin Ş,Kir G,Yilmaz M

MA5-16325 was used in immunohistochemistry to characterize a case where diagnosis of thyroid paraganglioma occurred by fine-needle aspiration biopsy and histopathological findings

Fri Jul 01 00:00:00 EDT 2016

Liquid-based cytologic findings of solitary extramedullary plasmacytoma in thyroid: a case report identified with fine-needle aspiration cytology.

Diagnostic cytopathology

Lee CH,Jung YY,Chung YR,Ryu HS

MA5-16325 was used in immunocytochemistry to report on a case of solitary extramedullary plasmacytoma of the thyroid

Sat Nov 01 00:00:00 EDT 2014

Calcitonin is expressed in the submaxillary glands of rats.

Bosnian journal of basic medical sciences

Zhang Y,Li B,Fu Z,Li S

MA5-16325 was used in immunocytochemistry and immunohistochemistry to study the rat submaxillary gland expression of calcitonin

Sat Feb 01 00:00:00 EST 2014

Absence of gene mutations in KIT-positive carcinoma showing thymus-like elements of the thyroid.

Human pathology

Pan Y,Zhao X,Yang J,Deng J,Zhan Z,Luo Y,Li Q,Guo Y,Zhai Q,Sun B

MA5-16325 was used in immunohistochemistry to study whether KIT mutations are involved in carcinoma showing thymus-like elements of the thyroid

Thu Mar 01 00:00:00 EST 2012

生物信息学

蛋白别名: Alpha CGRP; Alpha type CGRP; Alpha-type CGRP; Calcitonin; calcitonin 1; Calcitonin carboxyl-terminal peptide; calcitonin gene related peptide 1; Calcitonin gene-related peptide 1; Calcitonin gene-related peptide I; calcitonin-related polypeptide alpha; calcitonin/calcitonin-related polypeptide, alpha; CCP; CGRP-I; Katacalcin; katacalcin (KC); PDN-21

基因别名: CALC1; CALCA; CGRP; CGRP-I; CGRP1; CT; KC; PCT

UniProt ID: (Human) P06881

Entrez Gene ID: (Human) 796

分子生物学功能: peptide hormone

功能

vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure regulation of heart rate monocyte chemotaxis inflammatory response adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway embryo implantation aging feeding behavior response to heat negative regulation of ossification negative regulation of neurological system process activation of protein kinase activity cellular protein metabolic process positive regulation of adenylate cyclase activity positive regulation of ossification negative regulation of bone resorption negative regulation of transcription, DNA-templated negative regulation of smooth muscle contraction response to pain detection of temperature stimulus involved in sensory perception of pain positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway cellular response to tumor necrosis factor cellular response to nerve growth factor stimulus

参与通路

hormone activity protein binding calcitonin receptor binding identical protein binding

Calcitonin Monoclonal Antibody (SP17)

产品信息

MA5-16325

免疫组化 (IHC)

免疫组化（石蜡） (IHC (P))

免疫细胞化学 (ICC/IF)

种属反应

已发表种属

宿主/亚型

分类

类型

克隆号

抗原

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

RRID

产品详细信息

靶标信息

生物信息学

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