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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • Calmodulin 1/2/3 Antibodies

          Invitrogen

          Calmodulin 1/2/3 Polyclonal Antibody

          查看其他4个Calmodulin 1/2/3抗体
          说明书
          实验方案
          问题与答案
          技术支持
          说明书
          实验方案
          问题与答案
          技术支持

          Cite Calmodulin 1/2/3 Polyclonal Antibody

          • 抗体检测数据 (2)
          Calmodulin 1/2/3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          Calmodulin 1/2/3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          图: 1 / 2

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          Calmodulin 1/2/3 Antibody (PA5-104261) in IHC (P)

          Immunohistochemistry analysis of paraffin-embedded Calmodulin 3 in human brain tissues sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Calmodulin 3 polyclonal antibody (Product # PA5-104261) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit. {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
          已发表图片由___提供 benchsci-logo
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          Calmodulin 1/2/3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Calmodulin 1/2/3 Antibody in Western Blot (WB)

          产品信息

          PA5-104261

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          1:500-1:2,000
          -

          免疫组化(石蜡) (IHC (P))

          1:50-1:200
          -

          免疫细胞化学 (ICC/IF)

          1:100-1:500
          -
          产品规格

          种属反应

          Human, Mouse, Rat

          宿主/亚型

          Rabbit / IgG

          分类

          Polyclonal

          类型

          Antibody

          抗原

          A synthesized peptide derived from human CALM1(Accession P0DP23), corresponding to amino acid residues V56-L106.
          查看免疫原

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Liquid

          浓度

          1 mg/mL

          纯化类型

          Affinity chromatography

          保存液

          PBS, pH 7.4, with 50% glycerol

          内含物

          0.02% sodium azide

          保存条件

          -20°C

          运输条件

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2853575

          产品详细信息

          Antibody detects endogenous levels of total Calmodulin1/2/3.

          靶标信息

          Calmodulin is a small, highly conserved calcium binding protein found in all eukaryotic cells. With the capacity to bind up to four calcium ions, this 17 kDa protein acts as an important intracellular receptor for regulatory calcium signals. As it binds calcium, calmodulin undergoes conformational changes which can increase its affinity for target proteins. It acts both directly, through interaction with key target enzymes, and indirectly, via specific kinases. Studies have found that calmodulin participates in the regulation of several biological processes including energy and biosynthetic metabolism, cell motility, exocytosis, cytoskeletal assembly, and intracellular modulation of both cAMP and calcium concentrations.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          篇参考文献 (0)

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          引用该产品

          生物信息学

          蛋白别名: calmodulin; Calmodulin 1 (phosphorylase kinase, delta); calmodulin 2 (phosphorylase kinase, delta); calmodulin 3 (phosphorylase kinase, delta); Calmodulin III; Calmodulin-1; Calmodulin-2; Calmodulin-3; caM; epididymis secretory protein Li 72; LP7057 protein; phosphorylase kinase delta; phosphorylase kinase subunit delta; phosphorylase kinase, delta subunit; prepro-calmodulin 1; prepro-calmodulin 2; prepro-calmodulin 3

          查看更多 收起

          基因别名: 1500001E21Rik; AI256814; AI327027; AI461935; AL024000; AL024017; CALM; CALM1; CALM2; CALM3; CALML2; CAM; CAM1; CAM2; CAM3; CaMA; CAMB; CAMC; CAMI; CAMII; CAMIII; CPVT4; DD132; HEL-S-72; LQT14; LQT15; PHKD; PHKD2; PHKD3; R75142; RNCAMIII

          查看更多 收起

          UniProt ID: (Human) P0DP25, (Rat) P0DP31, (Mouse) P0DP28, (Mouse) Q498A3

          查看更多 收起

          Entrez Gene ID: (Human) 801, (Human) 805, (Human) 808, (Rat) 24242, (Mouse) 12313, (Rat) 50663, (Mouse) 12314, (Rat) 24244, (Mouse) 12315

          查看更多 收起

          功能
          Ras guanyl-nucleotide exchange factor activity calcium ion binding protein binding adenylate cyclase binding inositol-1,4,5-trisphosphate 3-kinase activity ligand-gated ion channel activity protein kinase binding protein domain specific binding nitric-oxide synthase regulator activity titin binding type 3 metabotropic glutamate receptor binding thioesterase binding N-terminal myristoylation domain binding phospholipase binding protein serine/threonine kinase activator activity phosphatidylinositol 3-kinase binding ion channel binding calcium-dependent protein binding nitric-oxide synthase binding protein phosphatase activator activity calcium channel regulator activity enzyme regulator activity protein N-terminus binding calmodulin-related
          参与通路
          G2/M transition of mitotic cell cycle MAPK cascade response to amphetamine regulation of heart rate platelet degranulation detection of calcium ion glycogen catabolic process muscle contraction G-protein coupled receptor signaling pathway activation of adenylate cyclase activity Wnt signaling pathway, calcium modulating pathway positive regulation of peptidyl-threonine phosphorylation negative regulation of peptidyl-threonine phosphorylation regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion substantia nigra development regulation of rhodopsin mediated signaling pathway positive regulation of cyclic nucleotide metabolic process positive regulation of protein autophosphorylation regulation of cytokinesis positive regulation of phosphoprotein phosphatase activity ion transmembrane transport positive regulation of protein dephosphorylation Fc-epsilon receptor signaling pathway positive regulation of DNA binding positive regulation of GTPase activity inositol phosphate metabolic process regulation of nitric-oxide synthase activity positive regulation of nitric-oxide synthase activity positive regulation of cyclic-nucleotide phosphodiesterase activity response to corticosterone response to calcium ion regulation of cardiac muscle contraction negative regulation of ryanodine-sensitive calcium-release channel activity positive regulation of ryanodine-sensitive calcium-release channel activity positive regulation of protein serine/threonine kinase activity regulation of high voltage-gated calcium channel activity regulation of cell communication by electrical coupling involved in cardiac conduction calcium-mediated signaling regulation of ryanodine-sensitive calcium-release channel activity regulation of store-operated calcium channel activity regulation of catalytic activity
          It has to be done as per old AB suggested Products section.
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