FIGURE: 1 / 1
Peptide Sequence: LLNRMAIKFK SFKTKGFGLD ACRCMINLMD KDGSGKLGLL EFKILWKKLK KWMDIFRECD QDHSGTLNSY EMRLVIEKAG IKLNNKVMQV LVARY
The calpains including Calpain 1 (CAPN1), calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. Diseases associated with CAPN1 include Spastic Paraplegia 76, Autosomal Recessive and Spasticity.
Protein Aliases: Calcium-activated neutral proteinase 11; Calpain-11; CANP 11; HIP2; LIG
Gene Aliases: calpain11; CAPN11
UniProt ID: (Human) Q9UMQ6
Entrez Gene ID: (Human) 11131
Molecular Function: cysteine protease