Search Thermo Fisher Scientific
Immunogen sequence: GDEADFTLRV FSERRHTAVE IDDVISADLQ SLQGPYLPLE LGLEQLFQEL AGEEEELNAS QLQALLSIAL EPARAHTSTP REIGLRT
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 80%.
The calpains including Calpain 1 (CAPN1), calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. Diseases associated with CAPN1 include Spastic Paraplegia 76, Autosomal Recessive and Spasticity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Calcium-activated neutral proteinase 12; Calpain-12; CANP 12
基因别名: CAPN12
UniProt ID: (Human) Q6ZSI9
Entrez Gene ID: (Human) 147968
分子生物学功能: cysteine protease