Immunogen sequence: GDEADFTLRV FSERRHTAVE IDDVISADLQ SLQGPYLPLE LGLEQLFQEL AGEEEELNAS QLQALLSIAL EPARAHTSTP REIGLRT
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 80%.
The calpains including Calpain 1 (CAPN1), calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. Diseases associated with CAPN1 include Spastic Paraplegia 76, Autosomal Recessive and Spasticity.