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Proteintech
Calsequestrin 2 Polyclonal Antibody
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产品信息
27560-1-AP
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Calsequestrin 2 Fusion Protein Ag26412 (273-399 aa encoded by BC022288)
偶联物
形式
Liquid
浓度
0.33 mg/mL
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: FAEKSDPDG YEFLEILKQV ARDNTDNPDL SILWIDPDDF PLLVAYWEKT FKIDLFRPQI GVVNVTDADS VWMEIPDDDD LPTAEELEDW IEDVLSGKIN TEDDDEDDDD DDNSDEEDND DSDDDDDE (273-399 aa encoded by BC022288)
靶标信息
Calsequestrin (CASQ) is a Ca2+-binding protein present primarily in junctional sarcoplasmic reticulum of skeletal and cardiac muscle; the cardiac form (CASQ2) is encoded by a separate gene. The primary role of CASQ2 is buffering of the sarcoplasmic reticulum Ca2+ ions, but another role for CASQ2 has emerged recently: CASQ2 regulates the open probability of ryanodine receptor 2 (RyR2). Mutations in CASQ2 cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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