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Proteintech
Calsequestrin 2 Monoclonal Antibody (1C10A1)
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产品信息
66419-1-IG
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Pig,
Rat
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
1C10A1
抗原
Calsequestrin 2 Fusion Protein Ag13246 (1-399 aa encoded by BC022288)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MKRTHLFIV GIYFLSSCRA EEGLNFPTYD GKDRVVSLSE KNFKQVLKKY DLLCLYYHEP VSSDKVTQKQ FQLKEIVLEL VAQVLEHKAI GFVMVDAKKE AKLAKKLGFD EEGSLYILKG DRTIEFDGEF AADVLVEFLL DLIEDPVEII SSKLEVQAFE RIEDYIKLIG FFKSEDSEYY KAFEEAAEHF QPYIKFFATF DKGVAKKLSL KMNEVDFYEP FMDEPIAIPN KPYTEEELVE FVKEHQRPTL RRLRPEEMFE TWEDDLNGIH IVAFAEKSDP DGYEFLEILK QVARDNTDNP DLSILWIDPD DFPLLVAYWE KTFKIDLFRP QIGVVNVTDA DSVWMEIPDD DDLPTAEELE DWIEDVLSGK INTEDDDEDD DDDDNSDEED NDDSDDDDDE (1-399 aa encoded by BC022288)
靶标信息
Calsequestrin (CASQ) is a Ca2+-binding protein present primarily in junctional sarcoplasmic reticulum of skeletal and cardiac muscle; the cardiac form (CASQ2) is encoded by a separate gene. The primary role of CASQ2 is buffering of the sarcoplasmic reticulum Ca2+ ions, but another role for CASQ2 has emerged recently: CASQ2 regulates the open probability of ryanodine receptor 2 (RyR2). Mutations in CASQ2 cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: calsequestrin 2 (cardiac muscle); calsequestrin 2, fast-twitch, cardiac muscle; Calsequestrin, cardiac muscle isoform; Calsequestrin-2; cardiac calsequestrin; SR calcium binding protein
基因别名: AA033488; AW146219; cardCSQ; CASQ2; cCSQ; Csq2; ESTM52; PDIB2
UniProt ID: (Human) O14958, (Mouse) O09161, (Rat) P51868
Entrez Gene ID: (Human) 845, (Pig) 397436, (Mouse) 12373, (Rat) 29209
regulation of heart rate
detection of calcium ion
striated muscle contraction
regulation of cell communication by electrical coupling
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
ion transmembrane transport
negative regulation of potassium ion transport
sarcomere organization
sequestering of calcium ion
protein polymerization
cardiac muscle contraction
regulation of membrane repolarization
negative regulation of ryanodine-sensitive calcium-release channel activity
cellular response to caffeine
Purkinje myocyte to ventricular cardiac muscle cell signaling
negative regulation of potassium ion transmembrane transporter activity
regulation of cardiac conduction
regulation of muscle contraction
regulation of cardiac muscle cell contraction
biological_process
