Invitrogen

Cardiac Troponin I Monoclonal Antibody (22B11)

产品信息

MA1-22701

应用	建议稀释比	已发表文章
免疫印迹 (WB)	Assay-dependent	-
酶联免疫吸附实验 (ELISA)	Assay-dependent	-

产品规格
种属反应	Human, Pig
宿主/亚型	Mouse / IgG2b
分类	Monoclonal
类型	Antibody
克隆号	22B11
抗原	Unphosphorylated form of cardiac troponin I (amino acid residues 20-24) 查看免疫原
偶联物	Unconjugated
形式	Liquid
浓度	4.9 mg/mL
纯化类型	Protein A
保存液	PBS, pH 7.4
内含物	0.09% sodium azide
保存条件	4° C, do not freeze
RRID	AB_561840

产品详细信息

MA1-22701 detects Cardiac Troponin 1 in Human and Porcine samples.

靶标信息

Cardiac Troponin I (Cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that exists as part of a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit of troponin binds to tropomyosin-t form, a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit, releases the inhibitory region of TnI from actin, anabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and hence movement. The measurements of blood TnI and TnT levels is an important diagnostics indicator of heart muscle damage, and can be used to differentiate between angina and myocardial infarction in patients with chest pains. Cardiac Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro. Mutations in the Cardiac Troponin I gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: Cardiac troponin I; cardiomyopathy, dilated 2A (autosomal recessive); MGC116817; Tpn1; troponin I type 3 (cardiac); Troponin I, cardiac muscle

基因别名: CMD1FF; CMD2A; CMH7; cTnI; RCM1; TNNC1; TNNI3

UniProt ID: (Human) P19429

Entrez Gene ID: (Human) 7137, (Pig) 100049696

分子生物学功能: non-motor actin binding protein