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Invitrogen
Cardiotin Monoclonal Antibody (SR-4)
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产品信息
MA1-06310
产品规格
种属反应
Human,
Pig
宿主/亚型
Mouse
/ IgM
分类
Monoclonal
类型
Antibody
克隆号
SR-4
抗原
Cardiotin purified from mouse spleen cells.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
purified
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA1-06310 detects cardiotin in human and porcine samples.
MA1-06310 has sucessfully been used in Western blotting and immunohistochemistry. By Western blotting, it detects a ~300 kDa protein representing cardiotin from.
The MA1-06310 immunogen is cardiotin purified from mouse spleen cells.
靶标信息
Cardiotin is a recently discovered, high molecular weight protein complex (~300 kDa) located in the longitudinal SR of cardiomyocytes. The cardiotin complex exists as 60 kDa and 100 kDa subunits. Both subunits contain the same amino-terminal 14 amino-acid sequence, and show high homology to human skeletal muscle alpha-actin. The tetrameric configuration of the cardiotin protein complex suggests that it exists as a transmembrane complex with the N-terminus at the cytoplasmic side of the membrane, able to interact with actin. Immunofluorescence studies colocalize cardiotin with SERCA 2a ATPase in the longitudinal sarcoplasmic reticulum (SR), although cardiotin is not expressed in junctional SR with SERCA 2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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