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Rockland
Caspase-13 Polyclonal Antibody
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Caspase-13 Antibody (600-401-AD0) in IHC (P)
Immunohistochemistry of Caspase-13 antibody. Tissue: Mouse brain tissue. Fixation: formalin fixed paraffin embedded. Antigen retrieval: not required. Primary antibody: Caspase-13 antibody at 10 µg/mL for 1 hr at RT. Secondary antibody: Peroxidase rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: Caspase-13 is localized in inflammasome complexes and the cytoplasm. Staining: Survivin as pr... View More
产品信息
600-401-AD0
产品规格
种属反应
Mouse,
Rat,
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Anti-Caspase-13 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 15 amino acid peptide near the N-terminus of human Caspase-13.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Ion-exchange chromatography
保存液
PBS, pH 7.2
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death is finally caused by members of the caspase family of proteases and caspase activated DNases. A novel member in the caspase family was recently identified and designated ERICE (for Evolutionarily Related Interleukin-1 beta Converting Enzyme) and caspase-13. Caspase-13 belongs to the ICE subfamily of caspases. Overexpression of caspase-13 induces apoptosis. Caspase-13 was activated by caspase-8, which is a key enzyme in death receptor induced apoptosis. Caspase-13 is expressed in a variety of human tissues and cell lines.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: apoptotic cysteine protease Mih1/TX; CASP-11; CASP-4; CASP13; caspase 11; caspase 4; caspase 4, apoptosis-related cysteine peptidase; caspase 4, apoptosis-related cysteine protease; Caspase-11; Caspase-4; ICE and Ced-3 homolog 2; ICE(rel)-II; ICH-2; MGC137679; Mih1; protease ICH-2; Protease ICH-3; Protease TX
基因别名: CASP-11; CASP-4; Casp11; CASP4; Caspl; ICE(rel)II; ICEREL-II; ICH-2; ich-3; ICH2; Ich3; Mih1; Mih1/TX; TX
UniProt ID: (Human) P49662, (Mouse) P70343
Entrez Gene ID: (Human) 837, (Rat) 114555, (Mouse) 12363
proteolysis
apoptotic process
inflammatory response
regulation of apoptotic process
innate immune response
regulation of inflammatory response
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
intrinsic apoptotic signaling pathway
cellular response to beta-amyloid
activation of cysteine-type endopeptidase activity involved in apoptotic process
substantia nigra development
ectopic germ cell programmed cell death
positive regulation of interleukin-1 beta secretion
pyroptosis
cellular response to mechanical stimulus
execution phase of apoptosis
