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Proteintech
Caspase 2 Monoclonal Antibody (2G4C2)
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产品信息
66517-1-IG
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
2G4C2
抗原
Caspase 2 Fusion Protein Ag20141 (170-325 aa encoded by BC002427)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This antibody can recognize the 32 kDa pro-caspase 2 as well as 18 kDa cleaved-caspase 2.
Immunogen sequence: GPLCLQVKP CTPEFYQTHF QLAYRLQSRP RGLALVLSNV HFTGEKELEF RSGGDVDHST LVTLFKLLGY DVHVLCDQTA QEMQEKLQNF AQLPAHRVTD SCIVALLSHG VEGAIYGVDG KLLQLQEVFQ LFDNANCPSL QNKPKMFFIQ ACRGDET (170-325 aa encoded by BC002427 )
靶标信息
Caspase 2 gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The proteolytic cleavage of this protein is induced by a variety of apoptotic stimuli. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CASP-2; caspase 2 apoptosis-related cysteine peptidase; Caspase-2; ICH-1L; ICH-1L/1S; NEDD-2; Neural precursor cell expressed developmentally down-regulated protein 2; Protease ICH-1; protein phosphatase 1, regulatory subunit 57
基因别名: CASP-2; CASP2; ICH1; NEDD-2; NEDD2; PPP1R57
UniProt ID: (Human) P42575
Entrez Gene ID: (Human) 835
luteolysis
neural retina development
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
brain development
aging
intrinsic apoptotic signaling pathway in response to DNA damage
protein processing
ectopic germ cell programmed cell death
regulation of apoptotic process
positive regulation of apoptotic process
positive regulation of neuron apoptotic process
cellular response to mechanical stimulus
apoptotic signaling pathway
extrinsic apoptotic signaling pathway in absence of ligand
execution phase of apoptosis
positive regulation of apoptotic signaling pathway
