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Proteintech
Caspase 4/p20/p10 Polyclonal Antibody
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产品信息
11856-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Caspase 4/p20/p10 Fusion Protein Ag2429 (1-377 aa encoded by BC017839)
偶联物
形式
Liquid
浓度
0.45 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MAEGNHRKK PLKVLESLGK DFLTGVLDNL VEQNVLNWKE EEKKKYYDAK TEDKVRVMAD SMQEKQRMAG QMLLQTFFNI DQISPNKKAH PNMEAGPPES GESTDALKLC PHEEFLRLCK ERAEEIYPIK ERNNRTRLAL IICNTEFDHL PPRNGADFDI TGMKELLEGL DYSVDVEENL TARDMESALR AFATRPEHKS SDSTFLVLMS HGILEGICGT VHDEKKPDVL LYDTIFQIFN NRNCLSLKDK PKVIIVQACR GANRGELWVR DSPASLEVAS SQSSENLEED AVYKTHVEKD FIAFCSSTPH NVSWRDSTMG SIFITQLITC FQKYSWCCHL EEVFRKVQQS FETPRAKAQM PTIERLSMTR YFYLFPGN (1-377 aa encoded by BC017839)
靶标信息
Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: apoptotic cysteine protease Mih1/TX; CASP-4; caspase 4, apoptosis-related cysteine peptidase; caspase 4, apoptosis-related cysteine protease; Caspase-4; ICE and Ced-3 homolog 2; ICE(rel)-II; ICH-2; Mih1; protease ICH-2; Protease TX
基因别名: CASP4; ICE(rel)II; ICEREL-II; ICH-2; ICH2; Mih1; Mih1/TX; TX
UniProt ID: (Human) P49662
Entrez Gene ID: (Human) 837
