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Proteintech
Caspase 9/p35/p10 Monoclonal Antibody (1B7G2)
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产品信息
66169-1-IG
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
1B7G2
抗原
Caspase 9/p35/p10 Fusion Protein Ag20813 (141-392 aa encoded by BC002452)
偶联物
形式
Liquid
浓度
1.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: ALESLRGNA DLAYILSMEP CGHCLIINNV NFCRESGLRT RTGSNIDCEK LRRRFSSLHF MVEVKGDLTA KKMVLALLEL AQQDHGALDC CVVVILSHGC QASHLQFPGA VYGTDGCPVS VEKIVNIFNG TSCPSLGGKP KLFFIQACGG EQKDHGFEVA STSPEDESPG SNPEPDATPF QEGLRTFDQL DAISSLPTPS DIFVSYSTFP GFVSWRDPKS GSWYVETLDD IFEQWAHSED LQSLLLRVAN AVS (141-392 aa encoded by BC002452)
靶标信息
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: APAF-3; apoptotic protease activating factor 3; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; CASP-9; caspase 9, apoptosis-related cysteine peptidase; Caspase-9; ICE-LAP6; ICE-like apoptotic protease 6; protein phosphatase 1, regulatory subunit 56
基因别名: AI115399; APAF-3; APAF3; AW493809; CASP-9; CASP9; Caspase-9; ICE-LAP6; MCH6; PPP1R56
UniProt ID: (Human) P55211, (Mouse) Q8C3Q9
Entrez Gene ID: (Human) 842, (Mouse) 12371
cysteine-type endopeptidase activity
protein binding
enzyme activator activity
peptidase activity
SH3 domain binding
protein kinase binding
cysteine-type endopeptidase activity involved in apoptotic process
cysteine-type peptidase activity
hydrolase activity
cysteine-type endopeptidase activity involved in apoptotic signaling pathway
protease
proteolysis
apoptotic process
cellular response to DNA damage stimulus
aging
intrinsic apoptotic signaling pathway in response to DNA damage
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
platelet formation
response to cobalt ion
response to estradiol
response to lipopolysaccharide
glial cell apoptotic process
cellular response to UV
signal transduction in response to DNA damage
positive regulation of neuron apoptotic process
response to antibiotic
cellular response to dexamethasone stimulus
extrinsic apoptotic signaling pathway in absence of ligand
regulation of response to DNA damage stimulus
activation of cysteine-type endopeptidase activity involved in apoptotic process
response to UV
response to organic cyclic compound
regulation of apoptotic process
positive regulation of apoptotic process
