The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
The cathepsin family of proteolytic enzymes include several diverse classes of proteases. Cathepsins B, L, H, K, S and O comprise the cysteine protease class. Cathepsins D and E comprise the aspartyle protease class. The serine protease class includes cathepsin G. Cathepsins function in cellular metabolism and participate in peptide biosynthesis and protein degradation. Cathepsin A, a serine carboxypeptidase, exists in a high molecular weight lysosomal complex with b-galactosidase (b-gal) and a-neuraminidase (Neu1). Cathepsin A functions to protect b-gal and Neu1 from intralysosomal proteolysis. Deficiencies in cathepsin A lead to deficiencies in b-gal and Neu1. The gene encoding human cathepsin A maps to chromosome 20q13.12. Mutations in this gene cause glactosialidosis, a lysosomal storage disorder resulting from the b-gal and Neu1 deficiencies.
蛋白别名: beta-galactosidase 2; beta-galactosidase protective protein; Carboxypeptidase C; Carboxypeptidase L; carboxypeptidase Y-like kininase; carboxypeptidase-L; Cathepsin A; deamidase; lysosomal carboxypeptidase A; Lysosomal protective protein; Lysosomal protective protein 20 kDa chain; Lysosomal protective protein 32 kDa chain; PPCA; Protective protein cathepsin A; Protective protein for beta-galactosidase; urinary kininase
基因别名: AU019505; CTSA; GLB2; GSL; NGBE; PPCA; PPGB
分子生物学功能: serine protease