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Invitrogen
Cathepsin A (Cleaved Arg326) Polyclonal Antibody
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Cathepsin A (Cleaved Arg326) Antibody (PA5-76127) in WB
Western blot analysis of Cathepsin A in Lane 1: HCT116 whole cell lysate (40 µg), Lane 2: L02 whole cell lysate (40 µg), Lane 3: HepG2 whole cell lysate (40 µg), Lane 4: AML-12 whole cell lysate (40 µg), Lane 5: PC12 whole cell lysate (40 µg), Lane 6: the Kidney tissue lysate of mouse (40 µg), Lane 7: the Kidney tissue lysate of rat (40 µg). Samples were incubated with Cathepsin A polyclonal antibody (Produ... View More
产品信息
PA5-76127
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids 291-340 of Human Cleaved-Cathepsin A.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
Cathepsin A, also known as protective protein/cathepsin A (PPCA), is a lysosomal serine protease encoded by the CTSA gene. It is a member of the alpha/beta hydrolase fold family, sharing structural homology with yeast carboxypeptidase Y. Cathepsin A functions predominantly in protein degradation within acidic endo/lysosomal compartments. It is involved in numerous physiological processes including intracellular protein degradation, energy metabolism, immune responses, and peptide synthesis. Particularly, the cleavage at Arg326 is significant as it pertains to its activation or functional modifications. Cathepsin A operates in conjunction with other enzymes such as neuraminidase and beta-galactosidase in a multi-enzyme complex, which is crucial for the lysosomal degradation pathways. Dysfunctions or mutations in the CTSA gene are associated with galactosialidosis, a lysosomal storage disorder characterized by a deficiency in these enzymatic activities.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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