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Invitrogen
Cathepsin D Polyclonal Antibody
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Cathepsin D Antibody (PA5-47046) in ICC/IF
Immunocytochemistry analysis of Cathepsin D in immersion fixed RAW 264.7 mouse monocyte/macrophage cell line. Samples were incubated in Cathepsin D polyclonal antibody (Product # PA5-47046) using a dilution of 5 µg/mL for 3 hours at room temperature followed by NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red) and counterstained with DAPI (blue). Specific staining was localized to lysoso... View More
产品信息
PA5-47046
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
已发表种属
C. elegans
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Mouse myeloma cell line NS0-derived recombinant mouse Cathepsin D Ile21-Leu410
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In direct ELISAs, approximately 20% cross-reactivity with recombinant human (rh) Cathepsin D is observed and less than 1% cross-reactivity with rhCathepsin A, B, C, L, X, and recombinant mouse (rm) Cathepsin B, C, H, and X is observed. In Western blots, approximately 100% cross-reactivity with rhCathepsin D is observed and less than 1% cross-reactivity with rmCathepsin E is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
Cathepsin D is a gene located on chromosome 11p15.5 that encodes a lysosomal aspartic protease involved in the degradation of proteins. This enzyme is widely expressed in various tissues but is particularly abundant in the liver, kidneys, and brain, where it plays a crucial role in intracellular protein catabolism and turnover. Cathepsin D is synthesized as an inactive precursor, procathepsin D, which is activated in the acidic environment of lysosomes. Beyond its fundamental role in protein degradation, Cathepsin D has been implicated in several physiological and pathological processes, including apoptosis, hormone processing, and antigen presentation. Dysregulation of Cathepsin D expression or activity is associated with various diseases, such as neurodegenerative disorders, cancer, and cardiovascular diseases. In the context of cancer, Cathepsin D overexpression has been linked to tumor progression and metastasis, making it a potential biomarker and therapeutic target. Research continues to explore its diverse biological functions and therapeutic implications in various medical conditions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Cathepsin D; CathepsinD; Ceroid lipofuscinosis neuronal 10; MGC2311; OTTHUMP00000196039; OTTHUMP00000198692
基因别名: CatD; CD; Ctsd
UniProt ID: (Mouse) P18242
Entrez Gene ID: (Mouse) 13033
