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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • Caveolin 1 Antibodies

          Invitrogen

          Caveolin 1 Polyclonal Antibody

          高级验证
          4个已发表图片
          9 篇参考文献
          查看其他32个Caveolin 1抗体

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          说明书
          实验方案
          问题与答案
          技术支持
          说明书
          实验方案
          问题与答案
          技术支持

          Cite Caveolin 1 Polyclonal Antibody

          • 抗体检测数据 (10)
          • 已发表图片 (4)
          • 高级验证 (3)
          Caveolin 1 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.
          Caveolin 1 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          图: 1 / 17

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          Caveolin 1 Antibody (PA5-17447) in ICC/IF

          Immunofluorescence analysis of Caveolin 1 was performed using 70% confluent log phase HeLa cells treated with 2 nM of Paclitaxel for 24 hr. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with Caveolin 1 Rabbit Polyclonal Antibody(Product # PA5-17447) at 1:100 di... View More {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
          已发表图片由___提供 benchsci-logo
          PMID: {{$ctrl.currentElement.benchSciPubmedId}}
          查看产品

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          Caveolin 1 Antibody in Immunocytochemistry (ICC/IF)
          Caveolin 1 Antibody in Immunocytochemistry (ICC/IF)
          Caveolin 1 Antibody in Immunocytochemistry (ICC/IF)
          Caveolin 1 Antibody in Immunocytochemistry (ICC/IF)
          Caveolin 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Caveolin 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Caveolin 1 Antibody in Western Blot (WB)
          Caveolin 1 Antibody in Western Blot (WB)
          Caveolin 1 Antibody in Western Blot (WB)
          Caveolin 1 Antibody in Western Blot (WB)
          Caveolin 1 Antibody in Western Blot, Immunoprecipitation (WB, IP)
          Caveolin 1 Antibody in Immunohistochemistry (IHC)
          Caveolin 1 Antibody in Western Blot (WB)
          Caveolin 1 Antibody in Western Blot (WB)
          Caveolin 1 Antibody
          Caveolin 1 Antibody
          Caveolin 1 Antibody

          产品信息

          PA5-17447

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          1:1,000
          查看2篇已发表文章 2篇已发表文章

          免疫组化 (IHC)

          -
          查看1篇已发表文章 1篇已发表文章

          免疫组化(石蜡) (IHC (P))

          1:250
          查看1篇已发表文章 1篇已发表文章

          免疫细胞化学 (ICC/IF)

          1:400
          查看3篇已发表文章 3篇已发表文章

          流式细胞分析 (Flow)

          1:50
          -

          免疫沉淀 (IP)

          1:50
          查看1篇已发表文章 1篇已发表文章

          其他PubMed (Misc)

          -
          查看1篇已发表文章 1篇已发表文章
          产品规格

          种属反应

          Bovine, Chicken, Hamster, Human, Mouse, Pig, Rat, Zebrafish

          已发表种属

          Dog, Human, Mouse

          宿主/亚型

          Rabbit / IgG

          分类

          Polyclonal

          类型

          Antibody

          抗原

          Synthetic peptide corresponding to residues surrounding Glu20 of human caveolin-1
          查看免疫原

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Liquid

          浓度

          33 µg/mL

          纯化类型

          Antigen affinity chromatography, Protein A

          保存液

          0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

          内含物

          no preservative

          保存条件

          -20°C

          运输条件

          Ambient (domestic); Wet ice (international)

          RRID

          AB_10985023

          产品详细信息

          It is not recommended to aliquot this antibody.

          This antibody is not cross-reactive with caveolin-2 or -3.

          靶标信息

          Caveolin-1 or CAV1 is a scaffolding proteins within caveolar membranes. It interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-1 is also involved in the co-stimulatory signal essential for T-cell receptor (TCR) mediated T-cell activation. It can bind with DPP4 and induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Mutations affecting the CAV1 gene can result in congenital generalized lipodystrophy 3, pulmonary hypertension primary 3, or partial lipodystrophy/congenital cataracts, and neurodegeneration syndrome.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          生物信息学

          蛋白别名: CAV1; caveolae; caveolin 1, caveolae protein, 22kDa; caveolin caveolae protein 22 kDa; caveolin, caveolae protein 1; caveolin, caveolae protein, 22 kDa; Caveolin-1; cell growth-inhibiting protein 32; HGNC:1527; OTTHUMP00000196475; variant a; variant b

          查看更多 收起

          基因别名: BSCL3; CAV; Cav-1; CAV1; Caveolin-1; CGL3; LCCNS; MSTP085; PPH3; VIP21; wu:fc07c04

          查看更多 收起

          UniProt ID: (Pig) Q6RVA9, (Chicken) P35431, (Bovine) P79132, (Human) Q03135, (Mouse) P49817

          查看更多 收起

          Entrez Gene ID: (Pig) 404693, (Chicken) 373996, (Bovine) 281040, (Human) 857, (Mouse) 12389, (Rat) 25404, (Chinese hamster) 100753021, (Zebrafish) 323695

          查看更多 收起

          功能
          protein kinase binding ion channel binding binding, bridging receptor binding peptidase activator activity protein binding, bridging identical protein binding macromolecular complex binding protein heterodimerization activity Rac GTPase binding nitric-oxide synthase binding ATPase binding inward rectifier potassium channel inhibitor activity RNA polymerase I transcription factor binding patched binding structural molecule activity protein binding cholesterol binding enzyme binding syntaxin binding protein complex scaffold MDM2/MDM4 family protein binding SNARE binding kinase binding beta-catenin binding scaffold/adaptor protein
          参与通路
          biological_process negative regulation of transforming growth factor beta receptor signaling pathway T cell costimulation receptor internalization negative regulation of endothelial cell proliferation cell differentiation regulation of cytosolic calcium ion concentration negative regulation of protein tyrosine kinase activity caveola assembly negative regulation of transcription from RNA polymerase II promoter inactivation of MAPK activity angiogenesis vasculogenesis response to hypoxia negative regulation of cytokine-mediated signaling pathway response to ischemia regulation of the force of heart contraction by chemical signal triglyceride metabolic process calcium ion transport regulation of smooth muscle contraction skeletal muscle tissue development lactation protein localization response to bacterium positive regulation of calcium ion transport into cytosol posttranscriptional regulation of gene expression positive regulation of gene expression positive regulation of cholesterol efflux positive regulation of peptidase activity receptor-mediated endocytosis of virus by host cell regulation of fatty acid metabolic process lipid storage regulation of blood coagulation positive regulation of cell migration negative regulation of epithelial cell differentiation negative regulation of protein ubiquitination positive regulation of protein ubiquitination negative regulation of protein binding positive regulation of protein binding response to progesterone negative regulation of peptidyl-serine phosphorylation positive regulation of peptidyl-serine phosphorylation nitric oxide homeostasis positive regulation of toll-like receptor 3 signaling pathway insulin receptor internalization vasoconstriction negative regulation of tyrosine phosphorylation of STAT protein cholesterol homeostasis response to estrogen negative regulation of nitric oxide biosynthetic process positive regulation of vasoconstriction negative regulation of pinocytosis negative regulation of nitric-oxide synthase activity positive regulation of NF-kappaB transcription factor activity response to calcium ion membrane depolarization mammary gland involution positive regulation of cell adhesion molecule production negative regulation of necroptotic process cellular response to exogenous dsRNA cellular response to hyperoxia cellular response to transforming growth factor beta stimulus basement membrane organization caveolin-mediated endocytosis regulation of heart rate by cardiac conduction angiotensin-activated signaling pathway involved in heart process negative regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway apoptotic signaling pathway regulation of membrane repolarization during action potential regulation of ventricular cardiac muscle cell action potential positive regulation of cold-induced thermogenesis regulation of ruffle assembly negative regulation of peptidyl-tyrosine autophosphorylation regulation of cell communication by electrical coupling involved in cardiac conduction positive regulation of ER-associated ubiquitin-dependent protein catabolic process positive regulation of gap junction assembly negative regulation of inward rectifier potassium channel activity receptor internalization involved in canonical Wnt signaling pathway regulation of entry of bacterium into host cell negative regulation of anoikis positive regulation of extrinsic apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway MAPK cascade positive regulation of endothelial cell proliferation cellular calcium ion homeostasis response to nutrient response to gamma radiation negative regulation of muscle cell apoptotic process vesicle organization cholesterol transport mammary gland development organ regeneration positive regulation of microtubule polymerization maintenance of protein location in cell cholesterol efflux wound healing response to drug negative regulation of tyrosine phosphorylation of Stat5 protein positive regulation of catalytic activity negative regulation of MAPK cascade protein localization to plasma membrane raft negative regulation of neuron differentiation positive regulation of endocytosis negative regulation of JAK-STAT cascade microtubule polymerization negative regulation of smooth muscle cell proliferation leukocyte migration regulation of nitric-oxide synthase activity protein homooligomerization response to glucocorticoid regulation of peptidase activity calcium ion homeostasis negative regulation of ERK1 and ERK2 cascade cellular response to mechanical stimulus cellular response to peptide hormone stimulus cellular senescence regulation of cardiac muscle cell action potential involved in regulation of contraction negative regulation of potassium ion transmembrane transport regulation of inward rectifier potassium channel activity protein localization to basolateral plasma membrane beta-catenin destruction complex disassembly negative regulation of cation channel activity regulation of the force of heart contraction endocytosis negative regulation of cell proliferation response to mechanical stimulus positive regulation of signal transduction negative regulation of signal transduction negative regulation of BMP signaling pathway negative regulation of MAP kinase activity protein oligomerization cellular response to starvation somitogenesis heart development dorsal/ventral pattern formation intestinal cholesterol absorption neuromast development regulation of defense response to virus notochord cell vacuolation cardiac muscle cell proliferation regulation of type I interferon-mediated signaling pathway cardiac muscle tissue regeneration
          It has to be done as per old AB suggested Products section.
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