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Proteintech
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Immunogen sequence: MVDYIVEYD YDAVHDDELT IRVGEIIRNV KKLQEEGWLE GELNGRRGMF PDNFVKEIKR ETEPKDDNLP IKRERQGNVA SLVQRISTYG LPAGGIQPHP QTKAIKKKTK KRQCKVLFDY SPQNEDELEL IVGDVIDVIE EVEEGWWSGT LNNKLGLFPS NFVKELESTE DGETHNAQEE SEVPLTGPTS PLPSPGNGSE PAPGSVAQPK KIRGIGFGDI FKEGSVKLRT RTSSSETEEK KTEKPLILQP LGSRTQNVEV TKPDVDGKIK AKEYCRTLFP YTGTNEDELT FREGEIIHLI SKETGEAGWW KGELNGKEGV FPDNFAVQIS ELDKDFPKPK KPPPPAKGPA PKPDLSAAEK KAFPLKAEEK DEKSLLEQKP SKPAAPQVPP KKPTAPTKAS NLLRSPGAVY PKRPEKPVPP PPPAAKINGE VSIISSKIDT EPVSKPKLDP EQLPVRPKSV DLDAFVARNS KETDDVNFDD IASSENLLHL TANRPKMPGR RLPGRFNGGH SPTQSPEKTL KLPKEDDSGN LKPLEFKKDA SYSSKPSLST PSSASKVNTA AFLTPLELKA KAEADDGKKN SVDELRAQII ELLCIVDALK KDHGKELEKL RKELEEEKAM RSNLEVEIAK LKKAVLLS (1-637 aa encoded by BC157901)
This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Adapter protein CMS; Cas ligand with multiple SH3 domains; Cas ligand with multiple Src homology 3 (SH3) domains; CD2-associated protein
基因别名: CD2AP; CMS
UniProt ID: (Human) Q9Y5K6
Entrez Gene ID: (Human) 23607